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Utilization of SARS-CoV-2-Positive donors in pediatric renal transplantation.
Pizzo, Helen; Soni, Priya R; Nadipuram, Santhosh; Garrison, Jonathan; Jordan, Stanley C; Puliyanda, Dechu.
Afiliación
  • Pizzo H; Pediatric Nephrology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Soni PR; Pediatric Infectious Disease, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Nadipuram S; Pediatric Infectious Disease, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Garrison J; Transplant Immunology Laboratory and Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Jordan SC; Transplant Immunology Laboratory and Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Puliyanda D; Pediatric Nephrology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Pediatr Transplant ; 27(5): e14451, 2023 08.
Article en En | MEDLINE | ID: mdl-36518031
BACKGROUND: As COVID-19-positive donors are becoming more common, there is an increasing need for the transplant community to evaluate the safety and efficacy of organ transplant from a SARS-CoV-2-infected donor. METHODS: Here we describe outcomes of two pediatric kidney transplant recipients who were vaccinated against COVID-19 and received their allograft from a SARS-CoV-2-positive donor. RESULTS: Both donors did not die from a COVID-19-related illness; the first donor had 1 week of COVID-19 symptoms 4 weeks prior to donation and the second was asymptomatic. Donor 1 had a Ct of 33.4 at 3 days and Donor 2 with a Ct of 37.2 at 16 days prior to donation. The first recipient was positive for SARS-CoV-2 anti-spike IgG on the day of transplant, but the second patient was negative and both patients received IVIg perioperatively. There was no evidence of SARS-CoV-2 transmission or compromised renal function at 86- and 80-day post-transplant, respectively. CONCLUSIONS: This case series suggests favorable short-term outcomes with accepting SARS-CoV-2-positive donors for pediatric renal transplantation, after thorough evaluation of the donor's risk for transmission, assessing the recipient's serologic status to SARS-CoV-2, and considering pre-emptive measures to mitigate the risk for severe COVID-19 should the recipient acquire donor-derived SARS-CoV-2.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Órganos / Trasplante de Riñón / COVID-19 Límite: Child / Humans Idioma: En Revista: Pediatr Transplant Asunto de la revista: PEDIATRIA / TRANSPLANTE Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Dinamarca
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Órganos / Trasplante de Riñón / COVID-19 Límite: Child / Humans Idioma: En Revista: Pediatr Transplant Asunto de la revista: PEDIATRIA / TRANSPLANTE Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Dinamarca