Quercetin-3-O-&#945;-L-arabinopyranosyl-(1â2)-ß-D-glucopyranoside Isolated from Eucommia ulmoides Leaf Relieves Insulin Resistance in HepG2 Cells via the IRS-1/PI3K/Akt/GSK-3ß Pathway.

Tang, Peng; Tang, Yong; Liu, Yan; He, Bing; Shen, Xin; Zhang, Zhi-Jie; Qin, Da-Lian; Tian, Ji

Quercetin-3-O-α-L-arabinopyranosyl-(1â2)-ß-D-glucopyranoside Isolated from Eucommia ulmoides Leaf Relieves Insulin Resistance in HepG2 Cells via the IRS-1/PI3K/Akt/GSK-3ß Pathway.

Tang, Peng; Tang, Yong; Liu, Yan; He, Bing; Shen, Xin; Zhang, Zhi-Jie; Qin, Da-Lian; Tian, Ji.

Afiliación

Tang P; Clinical Medical College & Affiliated Hospital of Chengdu University.
Tang Y; School of Pharmacy, Southwest Medical University.
Liu Y; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology.
He B; Sichuan Key Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Bioactivity Screening in Traditional Chinese Medicine and Druggability Evalution, School of Pharmacy, Southwest Medical University.
Shen X; Drug Discovery Research Center of Southwest Medical University.
Zhang ZJ; School of Pharmacy, Southwest Medical University.
Qin DL; Sichuan Key Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Bioactivity Screening in Traditional Chinese Medicine and Druggability Evalution, School of Pharmacy, Southwest Medical University.
Tian J; Department of Chinese Materia Medica, School of Pharmacy, Chengdu University of Traditional Chinese Medicine.

Biol Pharm Bull ; 46(2): 219-229, 2023 Feb 01.

Article en En | MEDLINE | ID: mdl-36517007

Asunto(s)

Eucommiaceae; Resistencia a la Insulina; Humanos; Eucommiaceae/metabolismo; Glucosa/metabolismo; Glucógeno; Glucógeno Sintasa Quinasa 3 beta; Células Hep G2; Insulina/farmacología; Simulación del Acoplamiento Molecular; Fosfatidilinositol 3-Quinasa; Fosfatidilinositol 3-Quinasas/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Quercetina/farmacología; Serina

Palabras clave

Eucommia ulmoides leaf; insulin; insulin receptor substrate (IRS)-1 phosphatidylinositol-3-kinase (PI3K) protein kinase B (Akt) glycogen synthase kinase (GSK)-3ß pathway; palmitic acid; quercetin glycoside; resistance

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Eucommiaceae Límite: Humans Idioma: En Revista: Biol Pharm Bull Asunto de la revista: BIOQUIMICA / FARMACOLOGIA Año: 2023 Tipo del documento: Article Pais de publicación: Japón

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