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A universal influenza mRNA vaccine candidate boosts T cell responses and reduces zoonotic influenza virus disease in ferrets.
van de Ven, Koen; Lanfermeijer, Josien; van Dijken, Harry; Muramatsu, Hiromi; Vilas Boas de Melo, Caroline; Lenz, Stefanie; Peters, Florence; Beattie, Mitchell B; Lin, Paulo J C; Ferreira, José A; van den Brand, Judith; van Baarle, Debbie; Pardi, Norbert; de Jonge, Jørgen.
Afiliación
  • van de Ven K; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.
  • Lanfermeijer J; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.
  • van Dijken H; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands.
  • Muramatsu H; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.
  • Vilas Boas de Melo C; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Lenz S; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.
  • Peters F; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.
  • Beattie MB; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.
  • Lin PJC; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada.
  • Ferreira JA; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada.
  • van den Brand J; Department of Statistics, Informatics and Modelling, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.
  • van Baarle D; Division of Pathology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.
  • Pardi N; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.
  • de Jonge J; Department of Medical Microbiology and Infection Prevention, Virology and Immunology Research Group, University Medical Center Groningen, Groningen, Netherlands.
Sci Adv ; 8(50): eadc9937, 2022 12 14.
Article en En | MEDLINE | ID: mdl-36516261
Universal influenza vaccines should protect against continuously evolving and newly emerging influenza viruses. T cells may be an essential target of such vaccines, as they can clear infected cells through recognition of conserved influenza virus epitopes. We evaluated a novel T cell-inducing nucleoside-modified messenger RNA (mRNA) vaccine that encodes the conserved nucleoprotein, matrix protein 1, and polymerase basic protein 1 of an H1N1 influenza virus. To mimic the human situation, we applied the mRNA vaccine as a prime-boost regimen in naïve ferrets (mimicking young children) and as a booster in influenza-experienced ferrets (mimicking adults). The vaccine induced and boosted broadly reactive T cells in the circulation, bone marrow, and respiratory tract. Booster vaccination enhanced protection against heterosubtypic infection with a potential pandemic H7N9 influenza virus in influenza-experienced ferrets. Our findings show that mRNA vaccines encoding internal influenza virus proteins represent a promising strategy to induce broadly protective T cell immunity against influenza viruses.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas contra la Influenza / Infecciones por Orthomyxoviridae / Gripe Humana / Subtipo H1N1 del Virus de la Influenza A / Subtipo H7N9 del Virus de la Influenza A Límite: Animals / Child / Child, preschool / Humans Idioma: En Revista: Sci Adv Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas contra la Influenza / Infecciones por Orthomyxoviridae / Gripe Humana / Subtipo H1N1 del Virus de la Influenza A / Subtipo H7N9 del Virus de la Influenza A Límite: Animals / Child / Child, preschool / Humans Idioma: En Revista: Sci Adv Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos