Your browser doesn't support javascript.
loading
Small Intestinal Bacterial Overgrowths and Intestinal Methanogen Overgrowths Breath Testing in a Real-Life French Cohort.
Plauzolles, Anne; Uras, Stella; Pénaranda, Guillaume; Bonnet, Marion; Dukan, Patrick; Retornaz, Frédérique; Halfon, Philippe.
Afiliación
  • Plauzolles A; Clinical Research and R&D Department, Laboratoire Européen Alphabio Biogroup, Marseille, France.
  • Uras S; Clinical Research and R&D Department, Laboratoire Européen Alphabio Biogroup, Marseille, France.
  • Pénaranda G; Faculty of Sciences, Aix-Marseille University, Marseille, France.
  • Bonnet M; Clinical Research and R&D Department, Laboratoire Européen Alphabio Biogroup, Marseille, France.
  • Dukan P; Clinical Research and R&D Department, Laboratoire Européen Alphabio Biogroup, Marseille, France.
  • Retornaz F; Infectious and Internal Medicine Department, Hôpital Européen Marseille, Marseille, France.
  • Halfon P; Infectious and Internal Medicine Department, Hôpital Européen Marseille, Marseille, France.
Clin Transl Gastroenterol ; 14(4): e00556, 2023 04 01.
Article en En | MEDLINE | ID: mdl-36515897
INTRODUCTION: Breath testing has become a widely used tool to diagnose small intestinal bacterial overgrowths (SIBOs) and intestinal methanogen overgrowths (IMOs) in clinical settings. Owing to the heterogeneity in clinical manifestations and lack of standardization among centers performing breath testing, SIBO and IMO can be easily overlooked by the clinician. We studied the prevalence and symptoms of SIBO/IMO in French patients referred for breath testing after seeking medical advice. METHODS: Breath test data and symptoms of 331 patients were assessed for SIBO/IMO using the H 2 /CH 4 lactulose breath test (LBT). Wilcoxon test or χ 2 test were used to compare patients with SIBO/IMO with patients without SIBO/IMO. LBT positive patients (H 2 +, CH 4 +, and CH 4 +/H 2 +) were compared using Kruskal-Wallis test for continuous data or χ 2 test for categorical data. RESULTS: Among the 186 (68.1%) patients tested positive for an overgrowth with 40.3%, 47.3%, and 12.4% for H 2 +, CH 4 + and CH 4 +/H 2 +, respectively, the presence of diarrhea was significantly increased in hydrogen type overgrowths ( P < 0.001). No significant difference according to age, gender, and symptoms was associated with a positive test except for joint pain that was less prevalent among LBT positive patients ( P = 0.038). In 86.5% of IMOs, positivity with CH 4 values ≥10 ppm could be identified at baseline. DISCUSSION: There are little discriminating symptoms that can help the clinician to identify patients likely to have a SIBO/IMO. However, SIBO/IMOs remain a common disorder widely underdiagnosed that need further studies to better apprehend functional bowel disorders.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Bacterianas / Síndrome del Asa Ciega Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Clin Transl Gastroenterol Año: 2023 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Bacterianas / Síndrome del Asa Ciega Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Clin Transl Gastroenterol Año: 2023 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos