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Local zinc treatment enhances fracture callus properties in diabetic rats.
Innella, Kevin; Levidy, Michael F; Kadkoy, Yazan; Lin, Anthony; Selles, Marcus; Sanchez, Alexandra; Weiner, Adam; Greendyk, Joshua; Moriarty, Brian; Lauritsen, Katherine; Lopez, Jonathan; Teitelbaum, Marc; Fisher, Mark; Mendiratta, Dhruv; Ahn, David B; Ippolitto, Joseph; Paglia, David N; Cottrell, Jessica; O'Connor, J Patrick; Benevenia, Joseph; Lin, Sheldon S.
Afiliación
  • Innella K; Department of Orthopaedic Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
  • Levidy MF; Department of Orthopaedic Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
  • Kadkoy Y; Department of Orthopaedic Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
  • Lin A; Department of Orthopaedic Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
  • Selles M; Department of Orthopaedic Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
  • Sanchez A; Department of Orthopaedic Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
  • Weiner A; Department of Orthopaedic Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
  • Greendyk J; Department of Orthopaedic Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
  • Moriarty B; Department of Orthopaedic Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
  • Lauritsen K; Department of Orthopaedic Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
  • Lopez J; Department of Orthopaedic Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
  • Teitelbaum M; Department of Orthopaedic Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
  • Fisher M; Department of Orthopaedic Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
  • Mendiratta D; Department of Orthopaedic Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
  • Ahn DB; Department of Orthopaedic Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
  • Ippolitto J; Department of Orthopaedic Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
  • Paglia DN; Department of Orthopaedic Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
  • Cottrell J; Department of Orthopaedic Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
  • O'Connor JP; Department of Biological Sciences, Seton Hall University, South Orange, New Jersey, USA.
  • Benevenia J; Department of Orthopaedic Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
  • Lin SS; Department of Orthopaedic Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
J Orthop Res ; 41(7): 1494-1504, 2023 07.
Article en En | MEDLINE | ID: mdl-36515300
The effects of locally applied zinc chloride (ZnCl2 ) on early and late-stage parameters of fracture healing were evaluated in a diabetic rat model. Type 1 Diabetes has been shown to negatively impact mechanical parameters of bone as well as biologic markers associated with bone healing. Zinc treatments have been shown to reverse those outcomes in tests of nondiabetic and diabetic animals. This study is the first to assess the efficacy of a noncarrier mediated ZnCl2 on bony healing in diabetic animals. This is a promising basic science approach which may lead to benefits for diabetic patients in the future. Treatment and healing were assessed through quantification of callus zinc, radiographic scoring, microcomputed tomography (µCT), histomorphometry, and mechanical testing. Local ZnCl2 treatment increased callus zinc levels at 1 and 3 days after fracture (p ≤ 0.025). Femur fractures treated with ZnCl2 showed increased mechanical properties after 4 and 6 weeks of healing. Histomorphometry of the ZnCl2 -treated fractures found increased callus cartilage area at Day 7 (p = 0.033) and increased callus bone area at Day 10 (p = 0.038). In contrast, callus cartilage area was decreased (p < 0.01) after 14 days in the ZnCl2 -treated rats. µCT analysis showed increased bone volume in the fracture callus of ZnCl2 -treated rats at 6 weeks (p = 0.0012) with an associated increase in the proportion of µCT voxel axial projections (Z-rays) spanning the fracture site. The results suggest that local ZnCl2 administration improves callus chondrogenesis leading to greater callus bone formation and improved fracture healing in diabetic rats.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Experimental / Fracturas del Fémur Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Orthop Res Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Experimental / Fracturas del Fémur Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Orthop Res Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos