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Vonoprazan in the management of gastric/peptic ulcers: a systematic review of safety data.
Moraes-Filho, Joaquim Prado P; Domingues, Gerson; Chinzon, Décio; Guedes, Juliana Leite Soares; Santos, Cláudia Yang; Zaterka, Schlioma.
Afiliación
  • Moraes-Filho JPP; Gastroenterology Department, Medical School, University of Sao Paulo, Sao Paulo, SP, Brazil.
  • Domingues G; Gastroenterology Department, Medical School, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Chinzon D; Gastroenterology Department, Medical School, University of Sao Paulo, Sao Paulo, SP, Brazil.
  • Guedes JLS; Takeda Pharmaceuticals, Brazil.
  • Santos CY; Takeda Pharmaceuticals, Brazil.
  • Zaterka S; Gastroenterology Department, Medical School, University of Sao Paulo, Sao Paulo, SP, Brazil.
Prz Gastroenterol ; 17(4): 266-273, 2022.
Article en En | MEDLINE | ID: mdl-36514456
Introduction: Although potassium-competitive acid blockers (P-CABs) prompted safety concerns when first developed, they ultimately proved to have a favourable safety profile. Aim: To assess the safety of vonoprazan in the management of gastroesophageal reflux disease (GERD), peptic ulcers, or gastroduodenal mucosal lesions induced by chronic use of aspirin or non-steroidal anti-inflammatory drugs (NSAIDs). Material and methods: From March to June 2021, a literature search was conducted using Medline via PubMed, Cochrane library, Lilacs, SciELO, and Centre for Reviews and Dissemination (CRD) electronic databases. After applying the eligibility criteria, 10 studies were included in this review. Of these 10 articles, vonoprazan was used as initial therapy in 6 and as maintenance therapy in 4. Adverse event rates were similar for vonoprazan and proton-pump inhibitors (PPIs). Conclusions: Our findings suggest that vonoprazan is a safe option for the management of erosive oesophagitis, gastric/peptic ulcers, or peptic ulcers induced by chronic use of aspirin or NSAIDs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Systematic_reviews Idioma: En Revista: Prz Gastroenterol Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Polonia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Systematic_reviews Idioma: En Revista: Prz Gastroenterol Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Polonia