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Phylogenetic analysis of congenital rubella virus from Indonesia: a case report.
Herini, Elisabeth Siti; Triono, Agung; Iskandar, Kristy; Nuady, Albaaza; Pujiastuti, Lucia Hetty; Nugrahanto, Andika Priamas; Kamal, Musthofa.
Afiliación
  • Herini ES; Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, 55281, Indonesia.
  • Triono A; Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, 55281, Indonesia.
  • Iskandar K; Department of Child Health/Genetics Working Group, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/UGM Academic Hospital, Yogyakarta, 55281, Indonesia.
  • Nuady A; Department of Ophthalmology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, 55281, Indonesia.
  • Pujiastuti LH; Department of Ophthalmology, Dr. Soeradji Tirtonegoro Hospital, Klaten, 57424, Indonesia.
  • Marcellus; Pediatric Surgery Division, Department of Surgery/Genetics Working Group, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, 55281, Indonesia.
  • Nugrahanto AP; Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, 55281, Indonesia.
  • Kamal M; World Health Organization (WHO) Indonesia Representative, Jakarta, 12940, Indonesia.
  • Gunadi; Pediatric Surgery Division, Department of Surgery/Genetics Working Group, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, 55281, Indonesia. drgunadi@ugm.ac.id.
BMC Pediatr ; 22(1): 713, 2022 12 13.
Article en En | MEDLINE | ID: mdl-36513987
BACKGROUND: Rubella is a common inherited infection resulting in congenital cataracts and a significant cause of permanent vision loss in developing countries. In 2016, Indonesia had the highest number of congenital rubella syndrome (CRS) cases globally. Here, we report the first genotype of the rubella virus extracted from the eye lens from a child with congenital cataracts due to CRS. CASE PRESENTATION: A female neonate was delivered by an elective caesarean delivery with normal birth weight at term from a 24-year-old mother in the rural setting. The baby presented with bilateral congenital cataracts, small-moderate secundum atrial septal defect, severe supravalvular pulmonary stenosis, and profound bilateral hearing loss. She also had microcephaly and splenomegaly. The patient's serology showed persistent positive IgG for rubella virus at the age of four years and four months. Following extraction during cataract surgery, viral detection of the lenses identified the presence of rubella. Phylogenetic analysis confirmed that the virus was grouped into genotype 1E. CONCLUSIONS: Our study reports the first phylogenetic analysis of the rubella virus extracted from the eye lens of a child with CRS in Indonesia. The detection of the rubella virus from eye lenses is remarkably promising. Our findings also emphasize the importance of molecular epidemiology in tracking the origin of rubella infection toward achieving virus eradication.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rubéola (Sarampión Alemán) / Catarata / Síndrome de Rubéola Congénita Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adult / Child / Child, preschool / Female / Humans / Infant / Newborn / Pregnancy País/Región como asunto: Asia Idioma: En Revista: BMC Pediatr Asunto de la revista: PEDIATRIA Año: 2022 Tipo del documento: Article País de afiliación: Indonesia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rubéola (Sarampión Alemán) / Catarata / Síndrome de Rubéola Congénita Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adult / Child / Child, preschool / Female / Humans / Infant / Newborn / Pregnancy País/Región como asunto: Asia Idioma: En Revista: BMC Pediatr Asunto de la revista: PEDIATRIA Año: 2022 Tipo del documento: Article País de afiliación: Indonesia Pais de publicación: Reino Unido