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TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults: A Secondary Analysis of the MAPT Study.
Giudici, Kelly Virecoulon; de Souto Barreto, Philipe; Guyonnet, Sophie; Morley, John E; Nguyen, Andrew D; Aggarwal, Geetika; Parini, Angelo; Li, Yan; Bateman, Randall John; Vellas, Bruno.
Afiliación
  • Giudici KV; Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU Toulouse), Toulouse, France.
  • de Souto Barreto P; Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU Toulouse), Toulouse, France.
  • Guyonnet S; CERPOP UMR1295, University of Toulouse III, INSERM, UPS, Toulouse, France.
  • Morley JE; Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU Toulouse), Toulouse, France.
  • Nguyen AD; CERPOP UMR1295, University of Toulouse III, INSERM, UPS, Toulouse, France.
  • Aggarwal G; Division of Geriatric Medicine, School of Medicine, Saint Louis University, St. Louis, Missouri, USA.
  • Parini A; Division of Geriatric Medicine, School of Medicine, Saint Louis University, St. Louis, Missouri, USA.
  • Li Y; Division of Geriatric Medicine, School of Medicine, Saint Louis University, St. Louis, Missouri, USA.
  • Bateman RJ; Institute of Metabolic and Cardiovascular Diseases (I2MC), INSERM UMR 1048, University of Toulouse III Paul Sabatier, Toulouse, France.
  • Vellas B; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
J Gerontol A Biol Sci Med Sci ; 78(4): 569-578, 2023 03 30.
Article en En | MEDLINE | ID: mdl-36508390
There is growing evidence that cognitive decline can be affected by both nutritional aspects and inflammation. Plasma neurodegenerative biomarkers stand out as minimally invasive useful measures to monitor the potential risk of cognitive decline. This study aimed to investigate the associations between biomarkers of neurodegeneration, nutrition, and inflammation among community-dwelling older adults, and to verify if associations differed according to apolipoprotein E (APOE) ε4 status. This cross-sectional analysis included 475 participants ≥70 years old from the Multidomain Alzheimer Preventive Trial (MAPT), mean age 76.8 years (SD = 4.5), 59.4% women. Biomarkers of neurodegeneration (plasma amyloid-ß 42/40-Aß 42/40, neurofilament light chain-NfL, progranulin), nutrition (erythrocyte docosahexaenoic acid, eicosapentaenoic acid, omega-3 index; plasma homocysteine-Hcy, 25 hydroxyvitamin D), inflammation (plasma tumor necrosis factor receptor 1-TNFR-1, monocyte chemoattractant protein 1-MCP-1, interleukin 6-IL-6), and cellular stress (plasma growth differentiation factor 15-GDF-15) were assessed. Linear regression analyses were performed to investigate the associations between nutritional and inflammatory biomarkers (independent variables) and neurodegenerative biomarkers (dependent variables), with adjustments for age, sex, education, body mass index, physical activity, allocation to MAPT groups, and APOE ε4 status. After adjusting for confounders, Aß 42/40 was not associated with nutritional or inflammatory markers. NfL was positively associated with GDF-15, TNFR-1, IL-6, and Hcy. Progranulin was positively associated with GDF-15, TNFR-1, and MCP-1. Analyses restricted to APOE ε4 carriers (n = 116; 26.9%) or noncarriers were mostly similar. Our cross-sectional study with community-dwelling older adults corroborates previous evidence that inflammatory pathways are associated to plasma markers of neurodegeneration. Clinical Trials Registration Number: NCT00672685.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Neurofilamentos / Enfermedades Neurodegenerativas / Receptores Tipo I de Factores de Necrosis Tumoral / Factor 15 de Diferenciación de Crecimiento / Enfermedad de Alzheimer / Progranulinas Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: J Gerontol A Biol Sci Med Sci Asunto de la revista: GERIATRIA Año: 2023 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Neurofilamentos / Enfermedades Neurodegenerativas / Receptores Tipo I de Factores de Necrosis Tumoral / Factor 15 de Diferenciación de Crecimiento / Enfermedad de Alzheimer / Progranulinas Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: J Gerontol A Biol Sci Med Sci Asunto de la revista: GERIATRIA Año: 2023 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos