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Joint effects of micro-sized polystyrene and chlorpyrifos on zebrafish based on multiple endpoints and gut microbial effects.
Huang, Zhiyi; Xiao, Xiangxiang; Wang, Dali; Zhong, Yuheng; Ding, Qi; You, Jing.
Afiliación
  • Huang Z; Guangdong Key Laboratory of Environmental Pollution and Health, Center for Environmental Microplastics Studies, School of Environment, Jinan University, Guangzhou 511443, China.
  • Xiao X; Guangdong Key Laboratory of Environmental Pollution and Health, Center for Environmental Microplastics Studies, School of Environment, Jinan University, Guangzhou 511443, China.
  • Wang D; Guangdong Key Laboratory of Environmental Pollution and Health, Center for Environmental Microplastics Studies, School of Environment, Jinan University, Guangzhou 511443, China. Electronic address: wdali2018@jnu.edu.cn.
  • Zhong Y; Guangdong Key Laboratory of Environmental Pollution and Health, Center for Environmental Microplastics Studies, School of Environment, Jinan University, Guangzhou 511443, China.
  • Ding Q; Guangdong Key Laboratory of Environmental Pollution and Health, Center for Environmental Microplastics Studies, School of Environment, Jinan University, Guangzhou 511443, China.
  • You J; Guangdong Key Laboratory of Environmental Pollution and Health, Center for Environmental Microplastics Studies, School of Environment, Jinan University, Guangzhou 511443, China.
J Environ Sci (China) ; 126: 184-197, 2023 Apr.
Article en En | MEDLINE | ID: mdl-36503748
Microplastics often co-occur with a variety of organic contaminants in aquatic environment and pose combined risks to aquatic wildlife. Here, we investigated joint effects of micro-sized polystyrene (mPS, 5 µm) and an organophosphate pesticide chlorpyrifos on zebrafish, using multiple endpoints at both fish individual and gut microbiota levels. It was revealed that mPS ingested by zebrafish accumulated in gut and liver, and caused oxidative stress, hyperactive swimming performance and histological damages in fish, and induced disorders and diversity alterations of the gut microbial community. More importantly, mPS exhibited considerable adsorption capacity against chlorpyrifos, and those adsorbing chlorpyrifos presented greater effects on fish individuals but no different effects on gut microbiota compared to single mPS exposure. Together with body residues of chlorpyrifos in zebrafish, it was proposed that the joint effects between mPS and chlorpyrifos were attributed to the chlorpyrifos released from mPS within zebrafish. The present results provided a comprehensive understanding of joint effects of mPS and contaminants co-occurring in the environment and emphasized the importance of considering the adsorbed chemicals in toxicological studies of microplastics.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cloropirifos / Microbioma Gastrointestinal Límite: Animals Idioma: En Revista: J Environ Sci (China) Asunto de la revista: SAUDE AMBIENTAL Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cloropirifos / Microbioma Gastrointestinal Límite: Animals Idioma: En Revista: J Environ Sci (China) Asunto de la revista: SAUDE AMBIENTAL Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos