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Altered structural and functional homotopic connectivity associated with the progression from mild cognitive impairment to Alzheimer's disease.
Chen, Shanshan; Wu, Huimin; Song, Yu; Ge, Honglin; Yan, Zheng; Xue, Chen; Qi, Wenzhang; Yuan, Qianian; Lin, Xingjian; Chen, Jiu.
Afiliación
  • Chen S; Department of Neurology, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
  • Wu H; Department of Neurology, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
  • Song Y; Department of Neurology, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
  • Ge H; Institute of Brain Functional Imaging, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
  • Yan Z; Institute of Brain Functional Imaging, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
  • Xue C; Department of Radiology, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
  • Qi W; Department of Radiology, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
  • Yuan Q; Department of Radiology, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
  • Lin X; Department of Neurology, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China. Electronic address: linxingjian@njmu.edu.cn.
  • Chen J; Department of Radiology, the Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China. Electronic address: ericcst@aliyun.com.
Psychiatry Res ; 319: 115000, 2023 01.
Article en En | MEDLINE | ID: mdl-36502711
The progressive mild cognitive impairment (pMCI) is associated with an increased risk of Alzheimer's disease (AD). Many studies have reported the disrupted brain alteration during the imminent conversion from pMCI to AD. However, the subtle difference of structural and functional of inter-hemispheric between pMCI and stable mild cognitive impairment (sMCI) remains unknown. In the present study, we scanned the multimodal magnetic resonance imaging of 38 sMCI, 26 pMCI, and 50 healthy controls (HC) and assessed the cognitive function. The voxel-mirrored homotopic connectivity (VMHC) and volume of corpus callosum were calculated. A structural equation modeling (SEM) was established to determine the relationships between the corpus callosum, the inter-hemispheric connectivity, and cognitive assessment. Compared to sMCI, pMCI exhibited decreased VMHC in insular and thalamus, and reduced volume of corpus callosum. SEM results showed that decreased inter-hemispheric connectivity was directly associated with cognitive impairment and corpus callosum atrophy, and corpus callosum atrophy indirectly caused cognitive impairment by mediating inter-hemispheric connectivity in pMCI. In conclusion, the destruction of homotopic connectivity is related to cognitive impairment, and the corpus callosum atrophy partially mediates the association between the homotopic connectivity and cognitive impairment in pMCI.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer / Disfunción Cognitiva Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Psychiatry Res Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer / Disfunción Cognitiva Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Psychiatry Res Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Irlanda