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Development of Biodegradable GQDs-hMSNs for Fluorescence Imaging and Dual Cancer Treatment via Photodynamic Therapy and Drug Delivery.
Reagen, Sarah; Wu, Yingfen; Sun, Di; Munoz, Carlos; Oncel, Nuri; Combs, Colin; Zhao, Julia Xiaojun.
Afiliación
  • Reagen S; Department of Chemistry, University of North Dakota, Grand Forks, ND 58202, USA.
  • Wu Y; Department of Chemistry, University of North Dakota, Grand Forks, ND 58202, USA.
  • Sun D; Department of Chemistry, University of North Dakota, Grand Forks, ND 58202, USA.
  • Munoz C; Department of Physics and Astrophysics, University of North Dakota, Grand Forks, ND 58202, USA.
  • Oncel N; Department of Physics and Astrophysics, University of North Dakota, Grand Forks, ND 58202, USA.
  • Combs C; Department of Biomedical Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
  • Zhao JX; Department of Chemistry, University of North Dakota, Grand Forks, ND 58202, USA.
Int J Mol Sci ; 23(23)2022 Nov 29.
Article en En | MEDLINE | ID: mdl-36499261
Recently, nano-based cancer therapeutics have been researched and developed, with some nanomaterials showing anticancer properties. When it comes to cancer treatment, graphene quantum dots (GQDs) contain the ability to generate 1O2, a reactive oxidative species (ROS), allowing for the synergistic imaging and photodynamic therapy (PDT) of cancer. However, due to their small particle size, GQDs struggle to remain in the target area for long periods of time in addition to being poor drug carriers. To address this limitation of GQDs, hollow mesoporous silica nanoparticles (hMSNs) have been extensively researched for drug delivery applications. This project investigates the utilization and combination of biomass-derived GQDs and Stöber silica hMSNs to make graphene quantum dots-hollow mesoporous silica nanoparticles (GQDs-hMSNs) for fluorescent imaging and dual treatment of cancer via drug delivery and photodynamic therapy (PDT). Although the addition of hMSNs made the newly synthesized nanoparticles slightly more toxic at higher concentrations, the GQDs-hMSNs displayed excellent drug delivery using fluorescein (FITC) as a mock drug, and PDT treatment by using the GQDs as a photosensitizer (PS). Additionally, the GQDs retained their fluorescence through the surface binding to hMSNs, allowing them to still be used for cell-labeling applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Puntos Cuánticos / Nanopartículas / Grafito / Neoplasias Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Puntos Cuánticos / Nanopartículas / Grafito / Neoplasias Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza