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Evaluation of carotid intima media thickness in children with idiopathic nephrotic syndrome.
Kamel, Ashraf Sayed; AlGhawass, Mohamed Mohamed Ezzat; Sayed, Muhammad Adel; Roby, Sara Aly.
Afiliación
  • Kamel AS; Pediatrics department, Faculty of Medicine, Fayoum University, Fayoum city, Egypt.
  • AlGhawass MME; Pediatrics department, Faculty of Medicine, Fayoum University, Fayoum city, Egypt.
  • Sayed MA; Pediatrics department, Faculty of Medicine, Fayoum University, Fayoum city, Egypt. mas19@fayoum.edu.eg.
  • Roby SA; Radiology department, Faculty of Medicine, Fayoum University, Fayoum city, Egypt.
Ital J Pediatr ; 48(1): 195, 2022 Dec 09.
Article en En | MEDLINE | ID: mdl-36494853
BACKGROUND: Nephrotic syndrome is the one of the commonest renal disorders in children. Children with nephrotic syndrome (NS) are at a high risk of atherosclerosis due to hyperlipidemia, hypertension. Carotid intima media thickness (CIMT) is a surrogate marker for atherosclerosis. This study aimed to evaluate the carotid intima media thickness in children with nephrotic syndrome and its relation to different risk factors. METHODS: This is an observational case control study that included forty children with nephrotic syndrome and thirty healthy children as controls. The inclusion criteria were: age of 2 years or more with disease duration of minimum of 1 year and glomerular filtration rate > 90 mL/min/1.73m2. CIMT was assessed by ultrasound. Lipid profile, protein/creatinine ratio in urine and kidney function tests were done. RESULTS: The mean CIMT (mm) was significantly higher in patients with NS (0.477 ± 0.04) compared to controls (0.39 ± 0.03) (P < 0.001) even when compared across different age groups. 60% of patients had received non-steroid immunosuppressive therapy. CIMT was significantly higher in patients receiving non-steroid immunosuppressive therapy than those receiving steroids alone. Subsequently, CIMT had significant positive correlation to duration of the disease (p = 0.05), body mass index (BMI) (p = 0.03), number of relapses (p = 0.01) and diastolic blood pressures (p = 0.003). CONCLUSION: Children with NS had significantly higher CIMT than control group. CIMT was positively correlated to disease duration, number of relapses and BMI. It was significantly higher among patients receiving non-steroid immunosuppressive therapy than those receiving steroids alone.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aterosclerosis / Síndrome Nefrótico Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Child / Child, preschool / Humans Idioma: En Revista: Ital J Pediatr Asunto de la revista: PEDIATRIA Año: 2022 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aterosclerosis / Síndrome Nefrótico Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Child / Child, preschool / Humans Idioma: En Revista: Ital J Pediatr Asunto de la revista: PEDIATRIA Año: 2022 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Reino Unido