A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal administration.

Ma, Huan; Zhang, Xinghai; Zeng, Weihong; Zhou, Junhui; Chi, Xiangyang; Chen, Shaohong; Zheng, Peiyi; Wang, Meihua; Wu, Yan; Zhao, Dan; Gong, Fanwu; Lin, Haofeng; Sun, Hancong; Yu, Changming; Shi, Zhengli; Hu, Xiaowen; Zhang, Huajun; Jin, Tengchuan; Chiu, Sandra

Ma, Huan; Zhang, Xinghai; Zeng, Weihong; Zhou, Junhui; Chi, Xiangyang; Chen, Shaohong; Zheng, Peiyi; Wang, Meihua; Wu, Yan; Zhao, Dan; Gong, Fanwu; Lin, Haofeng; Sun, Hancong; Yu, Changming; Shi, Zhengli; Hu, Xiaowen; Zhang, Huajun; Jin, Tengchuan; Chiu, Sandra.

Afiliación

Ma H; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
Zhang X; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China.
Zeng W; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
Zhou J; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China.
Chi X; University of Chinese Academy of Sciences, Beijing, China.
Chen S; Institute of Biotechnology, Academy of Military Medical Sciences, Beijing, China.
Zheng P; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China.
Wang M; University of Chinese Academy of Sciences, Beijing, China.
Wu Y; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
Zhao D; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
Gong F; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China.
Lin H; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
Sun H; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
Yu C; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China.
Shi Z; University of Chinese Academy of Sciences, Beijing, China.
Hu X; Institute of Biotechnology, Academy of Military Medical Sciences, Beijing, China.
Zhang H; Institute of Biotechnology, Academy of Military Medical Sciences, Beijing, China.
Jin T; CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China.
Chiu S; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.

Cell Discov ; 8(1): 132, 2022 Dec 09.

Article en En | MEDLINE | ID: mdl-36494344

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cell Discov Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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