Role of CXCL10 in Spinal Cord Injury.

Qiao, Xinyu; Zhang, Wei; Zhao, Weijiang

Qiao, Xinyu; Zhang, Wei; Zhao, Weijiang.

Afiliación

Qiao X; Wuxi School of Medicine, Jiangnan University, Wuxi 214122, Jiangsu, China.
Zhang W; Wuxi School of Medicine, Jiangnan University, Wuxi 214122, Jiangsu, China.
Zhao W; Department of Pathogen Biology, Guizhou Nursing Vocational College, Guiyang, China.

Int J Med Sci ; 19(14): 2058-2070, 2022.

Article en En | MEDLINE | ID: mdl-36483597

RESUMEN

Spinal cord injury (SCI) results in acute inflammatory responses and secondary damages, including neuronal and glial cell death, axonal damage and demyelination, and blood-brain barrier (BBB) damage, eventually leading to neuronal dysfunction and other complications. C-X-C motif Chemokine Ligand 10 (CXCL10) is expressed after the injury, playing multiple roles in the development and progression of SCI. Moreover, the CXCL10 antagonist can restrict inflammatory immune responses and promote neuronal regeneration and functional recovery. In this review, we summarize the structure and biological functions of CXCL10, and the roles of the CXCL10 / CXCR3 axis in acute inflammatory responses, secondary damages, and complications during SCI, thus providing a potential theoretical basis by highlighting CXCL10 as a new potential drug target for the treatment of SCI.

Asunto(s)

Traumatismos de la Médula Espinal; Humanos; Quimiocina CXCL10

Palabras clave

CXCL10; CXCR3; Complications; Inflammatory; Secondary damage; Spinal cord injury (SCI)

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal Límite: Humans Idioma: En Revista: Int J Med Sci Asunto de la revista: MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Australia

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google