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[Bleeding due to acquired factor V inhibitor successfully treated with platelet transfusion during treatment for recurrent prostate squamous cell carcinoma].
Kodama, Kaho; Hamaguchi, Maki; Yamada, Eiji; Tsuda, Nobuyuki; Sugimoto, Keiko; Nakamura, Saori; Kobayashi, Toshiaki; Wang, Shoulin; Minami, Hirohito; Fujieda, Atsushi; Shikami, Masato; Okamoto, Takashi; Ohnishi, Takehisa; Ii, Noriko; Tamaki, Shigehisa.
Afiliación
  • Kodama K; Department of Hematology, Japanese Red Cross Ise Hospital.
  • Hamaguchi M; Department of Hematology, Japanese Red Cross Ise Hospital.
  • Yamada E; Department of Hematology, Japanese Red Cross Ise Hospital.
  • Tsuda N; Department of Hematology, Japanese Red Cross Ise Hospital.
  • Sugimoto K; Department of Clinical Laboratory, Japanese Red Cross Ise Hospital.
  • Nakamura S; Department of Clinical Laboratory, Japanese Red Cross Ise Hospital.
  • Kobayashi T; Department of Hematology, Japanese Red Cross Ise Hospital.
  • Wang S; Department of Hematology, Japanese Red Cross Ise Hospital.
  • Minami H; Department of Hematology, Japanese Red Cross Ise Hospital.
  • Fujieda A; Department of Hematology, Japanese Red Cross Ise Hospital.
  • Shikami M; Department of Hematology, Japanese Red Cross Ise Hospital.
  • Okamoto T; Department of Urology, Japanese Red Cross Ise Hospital.
  • Ohnishi T; Department of Urology, Japanese Red Cross Ise Hospital.
  • Ii N; Department of Radiation Oncology, Japanese Red Cross Ise Hospital.
  • Tamaki S; Department of Hematology, Japanese Red Cross Ise Hospital.
Rinsho Ketsueki ; 63(11): 1508-1512, 2022.
Article en Ja | MEDLINE | ID: mdl-36476789
A 78-year-old man with prostate squamous cell carcinoma recurrence in his pelvis was admitted to our hospital. Rectal obstruction led to creation of an artificial anus on the transverse colon. Then, docetaxel and radiation therapies were started. A week later, severe hematuria and melena occurred. Activated partial thromboplastin time (APTT) and prothrombin time (PT) were extremely prolonged. Cross-mixing test for APTT and PT revealed an inhibitor pattern, which was diagnosed as acquired factor V inhibitor. Fresh frozen plasma and vitamin K infusions were ineffective, but platelet transfusion successfully stopped the bleeding. Platelet factor V derived from megakaryocytes may affect local hemostasis. The patient received prednisolone (PSL), and the inhibitor disappeared on day 70 and was in remission. PSL could be stopped on day 100. Later, we demonstrated APTT and PT shortening of factor V deficient plasma by the supernatant of activated platelets with collagen.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Próstata / Carcinoma de Células Escamosas Límite: Aged / Humans / Male Idioma: Ja Revista: Rinsho Ketsueki Año: 2022 Tipo del documento: Article Pais de publicación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Próstata / Carcinoma de Células Escamosas Límite: Aged / Humans / Male Idioma: Ja Revista: Rinsho Ketsueki Año: 2022 Tipo del documento: Article Pais de publicación: Japón