Infrared spectroscopy is suitable for objective assessment of articular cartilage health.

Virtanen, V; Tafintseva, V; Shaikh, R; Nippolainen, E; Haas, J; Afara, I O; Töyräs, J; Kröger, H; Solheim, J; Zimmermann, B; Kohler, A; Mizaikoff, B; Finnilä, M; Rieppo, L; Saarakkala, S

Virtanen, V; Tafintseva, V; Shaikh, R; Nippolainen, E; Haas, J; Afara, I O; Töyräs, J; Kröger, H; Solheim, J; Zimmermann, B; Kohler, A; Mizaikoff, B; Finnilä, M; Rieppo, L; Saarakkala, S.

Afiliación

Virtanen V; Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.
Tafintseva V; Faculty of Science and Technology, Norwegian University of Life Sciences, Ås, Norway.
Shaikh R; Department of Applied Physics, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
Nippolainen E; Department of Applied Physics, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
Haas J; Institute of Analytical and Bioanalytical Chemistry, Ulm University, Ulm, Germany.
Afara IO; Hahn-Schickard, Ulm, Germany.
Töyräs J; Department of Applied Physics, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
Kröger H; School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia.
Solheim J; Department of Applied Physics, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
Zimmermann B; Kuopio University Hospital, Kuopio, Finland.
Kohler A; Department of Orthopedics, Traumatology and Hand Surgery, Kuopio University Hospital, Kuopio, Finland.
Mizaikoff B; Faculty of Science and Technology, Norwegian University of Life Sciences, Ås, Norway.
Finnilä M; Faculty of Science and Technology, Norwegian University of Life Sciences, Ås, Norway.
Rieppo L; Faculty of Science and Technology, Norwegian University of Life Sciences, Ås, Norway.
Saarakkala S; Institute of Analytical and Bioanalytical Chemistry, Ulm University, Ulm, Germany.

Osteoarthr Cartil Open ; 4(2): 100250, 2022 Jun.

Article en En | MEDLINE | ID: mdl-36475284

RESUMEN

Objective: To evaluate the feasibility of Fourier transform infrared attenuated total reflectance (FTIR-ATR) spectroscopy to detect cartilage degradation due to osteoarthritis and to validate the methodology with osteochondral human cartilage samples for future development towards clinical use. Design: Cylindrical (d â= â4 âmm) osteochondral samples (n â= â349) were prepared from nine human cadavers and measured with FTIR-ATR spectroscopy. Afterwards, the samples were assessed with Osteoarthritis Research Society International (OARSI) osteoarthritis cartilage histopathology assessment system and divided into two groups: 1) healthy (OARSI 0-2) and 2) osteoarthritic (OARSI 2.5-6). The classification was done with partial least squares discriminant analysis model utilizing cross-model validation. Receiver operating characteristics curve analysis was performed and the area under curve (AUC) was calculated. Results: For all samples combined, classification accuracy was 73% with AUC of 0.79. Femoral samples had accuracy of 74% and AUC of 0.77, while tibial samples had accuracy of 66%, and AUC of 0.74. Patellar samples had accuracy of 84% and AUC of 0.91. Conclusions: The results indicate that FTIR-ATR spectroscopy can differentiate between healthy and osteoarthritic femoral, tibial and patellar human tissue. If combined with a fiber optic probe, FTIR-ATR spectroscopy could provide additional objective intraoperative information during arthroscopic surgeries, which could improve clinical outcomes.

Palabras clave

Arthroscopy; Cartilage; Fourier transform infrared spectroscopy; Osteoarthritis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Osteoarthr Cartil Open Año: 2022 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Reino Unido

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