N1-methyladenosine modification in cancer biology: Current status and future perspectives.
Comput Struct Biotechnol J
; 20: 6578-6585, 2022.
Article
en En
| MEDLINE
| ID: mdl-36467585
Post-transcriptional modifications in RNAs regulate their biological behaviors and functions. N1-methyladenosine (m1A), which is dynamically regulated by writers, erasers and readers, has been found as a reversible modification in tRNA, mRNA, rRNA and long non-coding RNA (lncRNA). m1A modification has impacts on the RNA processing, structure and functions of targets. Increasing studies reveal the critical roles of m1A modification and its regulators in tumorigenesis. Due to the positive relevance between m1A and cancer development, targeting m1A modification and m1A-related regulators has been of attention. In this review, we summarized the current understanding of m1A in RNAs, covering the modulation of m1A modification in cancer biology, as well as the possibility of targeting m1A modification as a potential target for cancer diagnosis and therapy.
AAA, Abdominal aortic aneurysm; ALKBH1, Alkb homologue 1; ALKBH3, Alkb homologue 3; ALKBH7, Alkb homologue 7; AML, Acute myeloid leukemia; BC, Breast cancer; BLCA, Bladder urothelial carcinoma; CC, Colon cancer; CRC, Colorectal cancer; Cancer biology; Diagnosis; FTO, Fat mass and obesity-associated protein; GBM, Glioblastoma multiforme; GI, Gastrointestinal cancer; HCC, Hepatocellular carcinoma; M1A; MA2, Meclofenamic acid 2; NML, Nucleomethylin; NSAID, Nonsteroidal anti-inflammatory drug; NSCLC, Non-small-cell lung cancer; Nm, Ribose-methylation; OC, Ovarian cancer; OSCC, Oral squamous cell carcinoma; PAAD, Pancreatic cancer; PC, Prostate cancer; R-2HG, R-2-hydroxyglutarate; RNA; SAM, S-adenosyl-l-methionine; TME, Tumor microenvironment; TRMT10C, tRNA methyltransferase 10C; TRMT6, tRNA methyltransferase 6; TRMT61A, tRNA methyltransferase 61A; TRMT61B, tRNA methyltransferase 61B; Therapy; UTR, 5' untranslated region; YTH, YT521-B homology; YTHDC1, YTH domain containing 1; YTHDF1, YTH domain family protein 1; YTHDF2, YTH domain family protein 2; YTHDF3, YTH domain family protein 3; cyt-tRNA, Cytoplasmic tRNA; hm5C, 5-hydroxymethylcytosine; lncRNA, Long non-coding RNA; m1A, N1-methyladenosine; m1I, 1-methylinosine; m5C, 5-methylcytidine; m6A, N6-methyladenosine; m6Am, N6,2'-O-dimethyladenosine; m7G, N7-methylguanosine; mt-tRNA, Mitochondrial tRNA; tDRs, tRNA-derived small RNAs; tRFs, tRNA fragments
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Comput Struct Biotechnol J
Año:
2022
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Países Bajos