Structural basis for the broad and potent cross-reactivity of an N501Y-centric antibody against sarbecoviruses.

Jeong, Bo-Seong; Jeon, Joon Young; Lai, Chih-Jen; Yun, Hye-Yeoung; Jung, Jae U; Oh, Byung-Ha

Jeong, Bo-Seong; Jeon, Joon Young; Lai, Chih-Jen; Yun, Hye-Yeoung; Jung, Jae U; Oh, Byung-Ha.

Afiliación

Jeong BS; Department of Biological Sciences, KAIST Institute for the Biocentury, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.
Jeon JY; Department of Protein Design, Therazyne, lnc., Daejeon, South Korea.
Lai CJ; Cancer Biology Department, Infection Biology Program, and Global Center for Pathogen and Human Health Research, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
Yun HY; New Target Team, Promedigen, lnc., Daejeon, South Korea.
Jung JU; Cancer Biology Department, Infection Biology Program, and Global Center for Pathogen and Human Health Research, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
Oh BH; Department of Biological Sciences, KAIST Institute for the Biocentury, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.

Front Immunol ; 13: 1049867, 2022.

Article en En | MEDLINE | ID: mdl-36466915

Asunto(s)

COVID-19; SARS-CoV-2; Humanos; Anticuerpos; Epítopos

Palabras clave

SARS-CoV-2; broad-spectrum vaccine; broadly neutralizing antibody; computational affinity maturation; key epitope; viral evolution

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 Límite: Humans Idioma: En Revista: Front Immunol Año: 2022 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Suiza

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