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Serum heavy metals and breast cancer risk: A case-control study nested in the Florence cohort of the EPIC (European Prospective Investigation into Cancer and nutrition) study.
Caini, Saverio; Cozzolino, Flavia; Saieva, Calogero; Aprea, Maria Cristina; De Bonfioli Cavalcabo', Nora; Ermini, Ilaria; Assedi, Melania; Biagiotti, Davide; Trane, Cinzia; Facchini, Luigi; Bendinelli, Benedetta; Palli, Domenico; Masala, Giovanna.
Afiliación
  • Caini S; Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Via Cosimo Il Vecchio 2, 50139 Florence, Italy. Electronic address: s.caini@ispro.toscana.it.
  • Cozzolino F; Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Via Cosimo Il Vecchio 2, 50139 Florence, Italy. Electronic address: f.cozzolino@ispro.toscana.it.
  • Saieva C; Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Via Cosimo Il Vecchio 2, 50139 Florence, Italy. Electronic address: c.saieva@ispro.toscana.it.
  • Aprea MC; Unit of Occupational and Environmental Toxicology - Public Health Laboratory, Department of Prevention, AUSL South-East Tuscany, Strada del Ruffolo 4, 53100 Siena, Italy. Electronic address: cristina.aprea@uslsudest.toscana.it.
  • De Bonfioli Cavalcabo' N; Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Via Cosimo Il Vecchio 2, 50139 Florence, Italy. Electronic address: n.debonfiolicavalcabo@ispro.toscana.it.
  • Ermini I; Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Via Cosimo Il Vecchio 2, 50139 Florence, Italy. Electronic address: i.ermini@ispro.toscana.it.
  • Assedi M; Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Via Cosimo Il Vecchio 2, 50139 Florence, Italy. Electronic address: m.assedi@ispro.toscana.it.
  • Biagiotti D; Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Via Cosimo Il Vecchio 2, 50139 Florence, Italy. Electronic address: d.biagiotti@ispro.toscana.it.
  • Trane C; Public Health Laboratory, Department of Technical Health Professions, Rehabilitation and Prevention, AUSL South-East Tuscany, Strada del Ruffolo 4, 53100 Siena, Italy. Electronic address: cinzia.trane@uslsudest.toscana.it.
  • Facchini L; Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Via Cosimo Il Vecchio 2, 50139 Florence, Italy. Electronic address: l.facchini@ispro.toscana.it.
  • Bendinelli B; Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Via Cosimo Il Vecchio 2, 50139 Florence, Italy. Electronic address: b.bendinelli@ispro.toscana.it.
  • Palli D; Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Via Cosimo Il Vecchio 2, 50139 Florence, Italy. Electronic address: d.palli@ispro.toscana.it.
  • Masala G; Clinical Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Via Cosimo Il Vecchio 2, 50139 Florence, Italy. Electronic address: g.masala@ispro.toscana.it.
Sci Total Environ ; 861: 160568, 2023 Feb 25.
Article en En | MEDLINE | ID: mdl-36464039
BACKGROUND: Chronic exposure to heavy metals is of concern for its potential carcinogenic effect. An association with increased breast cancer (BC) risk was hypothesized, but literature data are conflicting and the question remains unresolved. We aimed to investigate the association between heavy metals and BC risk in a case-control study nested within the Florence section of the EPIC (European Prospective Investigation into Cancer and nutrition) cohort. METHODS: We included 150 BC cases and an equal number of controls individually matched to cases by age and year of enrolment. In order to avoid confounding by smoking, the study was restricted to never smokers. Serum levels of six heavy metals (Cd, Co, Cr, Mn, Pb, and Tl) were quantified in pre-diagnostic samples using inductively coupled plasma mass spectrometry. Odds ratios (ORs) and corresponding 95 % confidence intervals (CI) were calculated via multivariable conditional logistic regression models. RESULTS: Serum levels of cobalt were inversely associated with BC risk (OR for the comparison of 3rd vs. 1st tertiles: 0.33, 95 % CI 0.12-0.91, p-value 0.033). None of the other heavy metals under study was significantly associated with BC risk in multivariable models. For Cd, Cr, and Tl, over half of the study participants had serum levels below the limit of quantitation. CONCLUSIONS: Our results do not support the hypothesis that exposure to heavy metals is associated with an increased BC risk among never smokers from the general population. The inverse association between cobalt serum levels and BC risk requires confirmation in future studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Metales Pesados Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Sci Total Environ Año: 2023 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Metales Pesados Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Sci Total Environ Año: 2023 Tipo del documento: Article Pais de publicación: Países Bajos