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L-arginine-containing mesoporous silica nanoparticles embedded in dental adhesive (Arg@MSN@DAdh) for targeting cariogenic bacteria.
López-Ruiz, Marta; Navas, Francisco; Fernández-García, Paloma; Martínez-Erro, Samuel; Fuentes, Mª Victoria; Giráldez, Isabel; Ceballos, Laura; Ferrer-Luque, Carmen Mª; Ruiz-Linares, Matilde; Morales, Victoria; Sanz, Raúl; García-Muñoz, Rafael A.
Afiliación
  • López-Ruiz M; Faculty of Health Sciences, IDIBO Research Group, Rey Juan Carlos University, Madrid, Spain.
  • Navas F; Department of Chemical and Environmental Technology, Rey Juan Carlos University, C/ Tulipán S/N Móstoles, 28933, Madrid, Spain.
  • Fernández-García P; Department of Chemical and Environmental Technology, Rey Juan Carlos University, C/ Tulipán S/N Móstoles, 28933, Madrid, Spain.
  • Martínez-Erro S; Department of Chemical and Environmental Technology, Rey Juan Carlos University, C/ Tulipán S/N Móstoles, 28933, Madrid, Spain.
  • Fuentes MV; Faculty of Health Sciences, IDIBO Research Group, Rey Juan Carlos University, Madrid, Spain.
  • Giráldez I; Faculty of Health Sciences, IDIBO Research Group, Rey Juan Carlos University, Madrid, Spain.
  • Ceballos L; Faculty of Health Sciences, IDIBO Research Group, Rey Juan Carlos University, Madrid, Spain. laura.ceballos@urjc.es.
  • Ferrer-Luque CM; Department of Stomatology, School of Dentistry, University of Granada, Campus de Cartuja, Colegio Máximo S/N, 18071, Granada, Spain.
  • Ruiz-Linares M; Department of Stomatology, School of Dentistry, University of Granada, Campus de Cartuja, Colegio Máximo S/N, 18071, Granada, Spain.
  • Morales V; Department of Chemical and Environmental Technology, Rey Juan Carlos University, C/ Tulipán S/N Móstoles, 28933, Madrid, Spain.
  • Sanz R; Department of Chemical and Environmental Technology, Rey Juan Carlos University, C/ Tulipán S/N Móstoles, 28933, Madrid, Spain.
  • García-Muñoz RA; Department of Chemical and Environmental Technology, Rey Juan Carlos University, C/ Tulipán S/N Móstoles, 28933, Madrid, Spain. rafael.garcia@urjc.es.
J Nanobiotechnology ; 20(1): 502, 2022 Dec 01.
Article en En | MEDLINE | ID: mdl-36457046
Dental caries is the major biofilm-mediated oral disease in the world. The main treatment to restore caries lesions consists of the use of adhesive resin composites due to their good properties. However, the progressive degradation of the adhesive in the medium term makes possible the proliferation of cariogenic bacteria allowing secondary caries to emerge. In this study, a dental adhesive incorporating a drug delivery system based on L-arginine-containing mesoporous silica nanoparticles (MSNs) was used to release this essential amino acid as a source of basicity to neutralize the harmful acidic conditions that mediate the development of dental secondary caries. The in vitro and bacterial culture experiments proved that L-arginine was released in a sustained way from MSNs and diffused out from the dental adhesive, effectively contributing to the reduction of the bacterial strains Streptococcus mutans and Lactobacillus casei. Furthermore, the mechanical and bonding properties of the dental adhesive did not change significantly after the incorporation of L-arginine-containing MSNs. These results are yielding glimmers of promise for the cost-effective prevention of secondary caries.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caries Dental / Nanopartículas Límite: Humans Idioma: En Revista: J Nanobiotechnology Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caries Dental / Nanopartículas Límite: Humans Idioma: En Revista: J Nanobiotechnology Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido