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Genetics of tibia bone properties of crossbred commercial laying hens in different housing systems.
Johnsson, Martin; Wall, Helena; Lopes Pinto, Fernando A; Fleming, Robert H; McCormack, Heather A; Benavides-Reyes, Cristina; Dominguez-Gasca, Nazaret; Sanchez-Rodriguez, Estefania; Dunn, Ian C; Rodriguez-Navarro, Alejandro B; Kindmark, Andreas; de Koning, Dirk-Jan.
Afiliación
  • Johnsson M; Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, 756 51 Uppsala, Sweden.
  • Wall H; Department of Animal Nutrition and Management, Swedish University of Agricultural Sciences, 750 07 Uppsala, Sweden.
  • Lopes Pinto FA; Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, 756 51 Uppsala, Sweden.
  • Fleming RH; The Roslin Institute, University of Edinburgh, Edinburgh EH25 9RG, UK.
  • McCormack HA; The Roslin Institute, University of Edinburgh, Edinburgh EH25 9RG, UK.
  • Benavides-Reyes C; Departamento de Mineralogía Y Petrologia, Universidad de Granada, 18002 Granada, Spain.
  • Dominguez-Gasca N; Departamento de Mineralogía Y Petrologia, Universidad de Granada, 18002 Granada, Spain.
  • Sanchez-Rodriguez E; Departamento de Mineralogía Y Petrologia, Universidad de Granada, 18002 Granada, Spain.
  • Dunn IC; The Roslin Institute, University of Edinburgh, Edinburgh EH25 9RG, UK.
  • Rodriguez-Navarro AB; Departamento de Mineralogía Y Petrologia, Universidad de Granada, 18002 Granada, Spain.
  • Kindmark A; Department of Medical Sciences, Uppsala University, Akademiska sjukhuset, 751 85 Uppsala, Sweden.
  • de Koning DJ; Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, 756 51 Uppsala, Sweden.
G3 (Bethesda) ; 13(2)2023 02 09.
Article en En | MEDLINE | ID: mdl-36453438
Osteoporosis and bone fractures are a severe problem for the welfare of laying hens, with genetics and environment, such as housing system, each making substantial contributions to bone strength. In this work, we performed genetic analyses of bone strength, bone mineral density, and bone composition, as well as body weight, in 860 commercial crossbred laying hens from 2 different companies, kept in either furnished cages or floor pens. We compared bone traits between housing systems and crossbreds and performed a genome-wide association study of bone properties and body weight. As expected, the 2 housing systems produced a large difference in bone strength, with layers housed in floor pens having stronger bones. These differences were accompanied by differences in bone geometry, mineralization, and chemical composition. Genome scans either combining or independently analyzing the 2 housing systems revealed no genome-wide significant loci for bone breaking strength. We detected 3 loci for body weight that were shared between the housing systems on chromosomes 4, 6, and 27 (either genome-wide significant or suggestive) and these coincide with associations for bone length. In summary, we found substantial differences in bone strength, content, and composition between hens kept in floor pens and furnished cages that could be attributed to greater physical activity in pen housing. We found little evidence for large-effect loci for bone strength in commercial crossbred hens, consistent with a highly polygenic architecture for bone strength in the production environment. The lack of consistent genetic associations between housing systems in combination with the differences in bone phenotypes could be due to gene-by-environment interactions with housing system or a lack of power to detect shared associations for bone strength.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tibia / Pollos Límite: Animals Idioma: En Revista: G3 (Bethesda) Año: 2023 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tibia / Pollos Límite: Animals Idioma: En Revista: G3 (Bethesda) Año: 2023 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido