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Practice-oriented solutions integrating intraoperative electron irradiation and personalized proton therapy for recurrent or unresectable cancers: Proof of concept and potential for dual FLASH effect.
Calvo, Felipe A; Ayestaran, Adriana; Serrano, Javier; Cambeiro, Mauricio; Palma, Jacobo; Meiriño, Rosa; Morcillo, Miguel A; Lapuente, Fernando; Chiva, Luis; Aguilar, Borja; Azcona, Diego; Pedrero, Diego; Pascau, Javier; Delgado, José Miguel; Aristu, Javier; Prezado, Yolanda.
Afiliación
  • Calvo FA; Department of Radiation Oncology, Clinica Universidad de Navarra, Madrid, Spain.
  • Ayestaran A; Department of Radiation Oncology, Clinica Universidad de Navarra, Madrid, Spain.
  • Serrano J; Department of Radiation Oncology, Clinica Universidad de Navarra, Madrid, Spain.
  • Cambeiro M; Department of Radiation Oncology, Clinica Universidad de Navarra, Madrid, Spain.
  • Palma J; Department of Radiation Oncology, Clinica Universidad de Navarra, Madrid, Spain.
  • Meiriño R; Department of Radiation Oncology, Clinica Universidad de Navarra, Madrid, Spain.
  • Morcillo MA; Medical Applications Unit, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain.
  • Lapuente F; Department of Surgery, Clinica Universidad de Navarra, Madrid, Spain.
  • Chiva L; Department of Gynecology and Obstretics, Clinica Universidad de Navarra, Madrid, Spain.
  • Aguilar B; Department of Medical Physics, Clinica Universidad de Navarra, Madrid, Spain.
  • Azcona D; Department of Medical Physics, Clinica Universidad de Navarra, Madrid, Spain.
  • Pedrero D; Department of Medical Physics, Clinica Universidad de Navarra, Madrid, Spain.
  • Pascau J; Department of Bioengineering and Aerospace Engineering, Universidad Carlos III de Madrid, Madrid, Spain.
  • Delgado JM; Department of Radiation Oncology, Clinica Universidad de Navarra, Madrid, Spain.
  • Aristu J; Department of Radiation Oncology, Clinica Universidad de Navarra, Madrid, Spain.
  • Prezado Y; Translational Research Department. Institut Curie, Université PSL, CNRS UMR, Inserm, Signalisation, Radiobiologie et Cancer, Orsay, France.
Front Oncol ; 12: 1037262, 2022.
Article en En | MEDLINE | ID: mdl-36452493
Background: Oligo-recurrent disease has a consolidated evidence of long-term surviving patients due to the use of intense local cancer therapy. The latter combines real-time surgical exploration/resection with high-energy electron beam single dose of irradiation. This results in a very precise radiation dose deposit, which is an essential element of contemporary multidisciplinary individualized oncology. Methods: Patient candidates to proton therapy were evaluated in Multidisciplinary Tumor Board to consider improved treatment options based on the institutional resources and expertise. Proton therapy was delivered by a synchrotron-based pencil beam scanning technology with energy levels from 70.2 to 228.7 MeV, whereas intraoperative electrons were generated in a miniaturized linear accelerator with dose rates ranging from 22 to 36 Gy/min (at Dmax) and energies from 6 to 12 MeV. Results: In a period of 24 months, 327 patients were treated with proton therapy: 218 were adults, 97 had recurrent cancer, and 54 required re-irradiation. The specific radiation modalities selected in five cases included an integral strategy to optimize the local disease management by the combination of surgery, intraoperative electron boost, and external pencil beam proton therapy as components of the radiotherapy management. Recurrent cancer was present in four cases (cervix, sarcoma, melanoma, and rectum), and one patient had a primary unresectable locally advanced pancreatic adenocarcinoma. In re-irradiated patients (cervix and rectum), a tentative radical total dose was achieved by integrating beams of electrons (ranging from 10- to 20-Gy single dose) and protons (30 to 54-Gy Relative Biological Effectiveness (RBE), in 10-25 fractions). Conclusions: Individual case solution strategies combining intraoperative electron radiation therapy and proton therapy for patients with oligo-recurrent or unresectable localized cancer are feasible. The potential of this combination can be clinically explored with electron and proton FLASH beams.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Oncol Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Oncol Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza