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Body mass index and molecular subtypes of colorectal cancer.
Murphy, Neil; Newton, Christina C; Song, Mingyang; Papadimitriou, Nikos; Hoffmeister, Michael; Phipps, Amanda I; Harrison, Tabitha A; Newcomb, Polly A; Aglago, Elom K; Berndt, Sonja I; Brenner, Hermann; Buchanan, Daniel D; Cao, Yin; Chan, Andrew T; Chen, Xuechen; Cheng, Iona; Chang-Claude, Jenny; Dimou, Niki; Drew, David; Farris, Alton B; French, Amy J; Gallinger, Steven; Georgeson, Peter; Giannakis, Marios; Giles, Graham G; Gruber, Stephen B; Harlid, Sophia; Hsu, Li; Huang, Wen-Yi; Jenkins, Mark A; Laskar, Ruhina S; Le Marchand, Loic; Limburg, Paul; Lin, Yi; Mandic, Marko; Nowak, Johnathan A; Obón-Santacana, Mereia; Ogino, Shuji; Qu, Conghui; Sakoda, Lori C; Schoen, Robert E; Southey, Melissa C; Stadler, Zsofia K; Steinfelder, Robert S; Sun, Wei; Thibodeau, Stephen N; Toland, Amanda E; Trinh, Quang M; Tsilidis, Kostas K; Ugai, Tomotaka.
Afiliación
  • Murphy N; Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.
  • Newton CC; Population Science Department, American Cancer Society (ACS), Atlanta, GA, USA.
  • Song M; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
  • Papadimitriou N; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Hoffmeister M; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Phipps AI; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Harrison TA; Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.
  • Newcomb PA; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Aglago EK; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
  • Berndt SI; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
  • Brenner H; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
  • Buchanan DD; Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, UK.
  • Cao Y; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Chan AT; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Chen X; Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, Australia.
  • Cheng I; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Melbourne, VIC, Australia.
  • Chang-Claude J; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, VIC, Australia.
  • Dimou N; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, MO, USA.
  • Drew D; Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.
  • Farris AB; Alvin J. Siteman Cancer Center, St Louis, MO, USA.
  • French AJ; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Gallinger S; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Georgeson P; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Giannakis M; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Giles GG; Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany.
  • Gruber SB; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
  • Harlid S; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Hsu L; Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
  • Huang WY; Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.
  • Jenkins MA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Laskar RS; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Le Marchand L; Department of Pathology, Emory University, Atlanta, GA, USA.
  • Limburg P; Division of Laboratory Genetics, Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN, USA.
  • Lin Y; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
  • Mandic M; Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC, Australia.
  • Nowak JA; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Melbourne, VIC, Australia.
  • Obón-Santacana M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Ogino S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Qu C; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
  • Sakoda LC; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
  • Schoen RE; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.
  • Southey MC; Department of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA.
  • Stadler ZK; Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.
  • Steinfelder RS; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
  • Sun W; Department of Biostatistics, University of Washington, Seattle, WA, USA.
  • Thibodeau SN; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Toland AE; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
  • Trinh QM; Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.
  • Tsilidis KK; University of Hawaii Cancer Center, Epidemiology Program, Honolulu, HI, USA.
  • Ugai T; Mayo Clinic, Rochester, MN, USA.
J Natl Cancer Inst ; 115(2): 165-173, 2023 02 08.
Article en En | MEDLINE | ID: mdl-36445035
BACKGROUND: Obesity is an established risk factor for colorectal cancer (CRC), but the evidence for the association is inconsistent across molecular subtypes of the disease. METHODS: We pooled data on body mass index (BMI), tumor microsatellite instability status, CpG island methylator phenotype status, BRAF and KRAS mutations, and Jass classification types for 11 872 CRC cases and 11 013 controls from 11 observational studies. We used multinomial logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) adjusted for covariables. RESULTS: Higher BMI was associated with increased CRC risk (OR per 5 kg/m2 = 1.18, 95% CI = 1.15 to 1.22). The positive association was stronger for men than women but similar across tumor subtypes defined by individual molecular markers. In analyses by Jass type, higher BMI was associated with elevated CRC risk for types 1-4 cases but not for type 5 CRC cases (considered familial-like/Lynch syndrome microsatellite instability-H, CpG island methylator phenotype-low or negative, BRAF-wild type, KRAS-wild type, OR = 1.04, 95% CI = 0.90 to 1.20). This pattern of associations for BMI and Jass types was consistent by sex and design of contributing studies (cohort or case-control). CONCLUSIONS: In contrast to previous reports with fewer study participants, we found limited evidence of heterogeneity for the association between BMI and CRC risk according to molecular subtype, suggesting that obesity influences nearly all major pathways involved in colorectal carcinogenesis. The null association observed for the Jass type 5 suggests that BMI is not a risk factor for the development of CRC for individuals with Lynch syndrome.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Neoplasias Colorrectales Hereditarias sin Poliposis Tipo de estudio: Observational_studies Límite: Female / Humans Idioma: En Revista: J Natl Cancer Inst Año: 2023 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Neoplasias Colorrectales Hereditarias sin Poliposis Tipo de estudio: Observational_studies Límite: Female / Humans Idioma: En Revista: J Natl Cancer Inst Año: 2023 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos