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Optimization of a laparoscopic procedure for advanced intrahepatic cholangiocarcinoma based on the concept of "waiting time": a preliminary report.
Liao, Cheng-Yu; Wang, Dan-Feng; Jiang, Bin-Hua; Huang, Long; Lin, Tian-Sheng; Qiu, Fu-Nan; Zhou, Song-Qiang; Wang, Yao-Dong; Zheng, Xiao-Chun; Tian, Yi-Feng; Chen, Shi.
Afiliación
  • Liao CY; Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
  • Wang DF; Department of Hepatobiliary Pancreatic Surgery, Fujian Provincial Hospital, Fuzhou, 350001, China.
  • Jiang BH; Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
  • Huang L; Department of Anesthesiology, Fujian Provincial Hospital, Fuzhou, 350001, China.
  • Lin TS; Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
  • Qiu FN; Department of Hepatobiliary Pancreatic Surgery, Fujian Provincial Hospital, Fuzhou, 350001, China.
  • Zhou SQ; Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
  • Wang YD; Department of Hepatobiliary Pancreatic Surgery, Fujian Provincial Hospital, Fuzhou, 350001, China.
  • Zheng XC; Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
  • Tian YF; Department of Hepatobiliary Pancreatic Surgery, Fujian Provincial Hospital, Fuzhou, 350001, China.
  • Chen S; Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
BMC Cancer ; 22(1): 1222, 2022 Nov 28.
Article en En | MEDLINE | ID: mdl-36443693
INTRODUCTION: Clinicians increasingly perform laparoscopic surgery for intrahepatic cholangiocarcinoma (ICC). However, this surgery can be difficult in patients with advanced-stage ICC because of the complicated procedures and difficulty in achieving high-quality results. We compared the effects of a three-step optimized procedure with a traditional procedure for patients with advanced-stage ICC. METHODS: Forty-two patients with advanced-stage ICC who received optimized laparoscopic hemihepatectomy with lymph node dissection (LND, optimized group) and 84 propensity score-matched patients who received traditional laparoscopic hemihepatectomy plus LND (traditional group) were analyzed. Surgical quality, disease-free survival (DFS), and overall survival (OS) were compared. RESULTS: The optimized group had a lower surgical bleeding score (P = 0.038) and a higher surgeon satisfaction score (P = 0.001). Blood loss during hepatectomy was less in the optimized group (190 vs. 295 mL, P < 0.001). The optimized group had more harvested LNs (12.0 vs. 8.0, P < 0.001) and more positive LNs (8.0 vs. 5.0, P < 0.001), and a similar rate of adequate LND (88.1% vs. 77.4%, P = 0.149). The optimized group had longer median DFS (9.0 vs. 7.0 months, P = 0.018) and median OS (15.0 vs. 13.0 months, P = 0.046). In addition, the optimized group also had a shorter total operation time (P = 0.001), shorter liver resection time (P = 0.001), shorter LND time (P < 0.001), shorter hospital stay (P < 0.001), and lower incidence of total morbidities (14.3% vs. 36.9%, P = 0.009). CONCLUSIONS: Our optimization of a three-step laparoscopic procedure for advanced ICC was feasible, improved the quality of liver resection and LND, prolonged survival, and led to better intraoperative and postoperative outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de los Conductos Biliares / Laparoscopía / Colangiocarcinoma Límite: Humans Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de los Conductos Biliares / Laparoscopía / Colangiocarcinoma Límite: Humans Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido