Gem-Difluoroallylation of Aryl Sulfonium Salts.

Zhao, Yue; Empel, Claire; Liang, Wenjing; Koenigs, Rene M; Patureau, Frederic W

Zhao, Yue; Empel, Claire; Liang, Wenjing; Koenigs, Rene M; Patureau, Frederic W.

Afiliación

Zhao Y; Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, Aachen 52074, Germany.
Empel C; Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, Aachen 52074, Germany.
Liang W; Institute of Physical Chemistry, RWTH Aachen University, Landoltweg 1, Aachen 52074, Germany.
Koenigs RM; Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, Aachen 52074, Germany.
Patureau FW; Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, Aachen 52074, Germany.

Org Lett ; 24(48): 8753-8758, 2022 12 09.

Article en En | MEDLINE | ID: mdl-36440861

RESUMEN

The unprecedented photochemical late-stage defluorinative gem-difluoroallylation of aryl sulfonium salts, which are formed site-selectively by direct C(sp2)âH functionalization, is herein disclosed. This method is distinguished by its mild reaction conditions, wide scope, and excellent site-selectivity. As showcase examples, a Flurbiprofen and Pyriproxyfen derivatives could be late stage C(sp2)âH gem-difluoroallylated with high yields. Experimental and computational investigations were conducted.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos

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