Your browser doesn't support javascript.
loading
Hypomethylating agent-based therapies in older adults with acute myeloid leukemia - A joint review by the Young International Society of Geriatric Oncology and European Society for Blood and Marrow Transplantation Trainee Committee.
Neuendorff, Nina Rosa; Gagelmann, Nico; Singhal, Surbhi; Meckstroth, Shelby; Thibaud, Vincent; Zhao, Yue; Mir, Nabiel; Shih, Yung-Yu; Amaro, Danielle M C; Roy, Mukul; Lombardo, Joseph; Gjærde, Lars Klingen; Loh, Kah Poh.
Afiliación
  • Neuendorff NR; Clinic for Hematology and Stem-Cell Transplantation, University Hospital Essen, Hufelandstrasse 55, D-45147 Essen, Germany. Electronic address: nina.neuendorff@uk-essen.de.
  • Gagelmann N; Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Singhal S; Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Meckstroth S; Louisiana State University Health Sciences Center, School of Medicine, New Orleans, LA, USA.
  • Thibaud V; Department of Hematology, Hôpital Saint-Vincent, Université Catholique de Lille, 59000 Lille, France.
  • Zhao Y; Department of General, Visceral, Cancer and Transplantation Surgery, University Hospital Cologne, 50937 Cologne, Germany.
  • Mir N; Section of Geriatrics and Palliative Medicine, The University of Chicago Medical Center, Chicago, USA.
  • Shih YY; Department of Hematology and Oncology, Clinic Favoriten Vienna, Austria.
  • Amaro DMC; Department of Oncology and Hematology, Hospital Israelita Albert Einstein, São Paulo, Brazil.
  • Roy M; Department of Radiation Oncology, Jaslok Hospital, Mumbai, India.
  • Lombardo J; Department of Radiation Oncology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA.
  • Gjærde LK; Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • Loh KP; Division of Hematology/Oncology, Department of Medicine, James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.
J Geriatr Oncol ; 14(3): 101406, 2023 04.
Article en En | MEDLINE | ID: mdl-36435726
Acute myeloid leukemia (AML) is associated with poor outcomes in older adults. A major goal of treatment is to balance quality of life and functional independence with disease control. With the approval of new, more tolerable regimens, more older adults are able to receive AML-directed therapy. Among these options are hypomethylating agents (HMAs), specifically azacitidine and decitabine. HMAs have become an integral part of AML therapy over the last two decades. These agents are used either as monotherapy or nowadays more commonly in combination with other agents such as the Bcl-2 inhibitor venetoclax. Biological AML characteristics, such as molecular and cytogenetic risk factors, play crucial roles in guiding treatment decisions. In patients with high-risk AML, HMAs are increasingly used rather than intensive chemotherapy, although further trials based on a risk-adapted approach using patient- and disease-related factors are needed. Here, we review trials and evidence for the use of HMA monotherapy and combination therapy in the management of older adults with AML. Furthermore, we discuss the use of HMAs and HMA combination therapies in AML, mechanisms of action, their incorporation into hematopoietic stem cell transplantation strategies, and their use in patients with comorbidities and reduced organ function.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Antineoplásicos Tipo de estudio: Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Aged / Humans Idioma: En Revista: J Geriatr Oncol Año: 2023 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Antineoplásicos Tipo de estudio: Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Aged / Humans Idioma: En Revista: J Geriatr Oncol Año: 2023 Tipo del documento: Article Pais de publicación: Países Bajos