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CD47 mediates the progression of colorectal cancer by inducing tumor cell apoptosis and angiogenesis.
Oh, Hyung-Hoon; Park, Young-Lan; Park, Sun-Young; Myung, Eun; Im, Chan-Muk; Yu, Hyung-Joo; Han, Bora; Seo, Yoon-Jin; Kim, Ki-Hyun; Myung, Dae-Seong; Cho, Sung-Bum; Lee, Wan-Sik; Park, Daeho; Joo, Young-Eun.
Afiliación
  • Oh HH; Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Park YL; Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Park SY; Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Myung E; Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Im CM; Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Yu HJ; Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Han B; Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Seo YJ; Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Kim KH; Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Myung DS; Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Cho SB; Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Lee WS; Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
  • Park D; School of Life Sciences and Bio Imaging Research Center, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.
  • Joo YE; Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea. Electronic address: yejoo@chonnam.ac.kr.
Pathol Res Pract ; 240: 154220, 2022 Dec.
Article en En | MEDLINE | ID: mdl-36434854
CD47 is an immunoregulatory protein that is found on the cell surface and plays significant roles in cellular functions such as proliferation, apoptosis, migration, and immune homeostasis. CD47 is overexpressed in various human cancers and is associated with tumor development, progression, and poor prognosis. In this study, we analyzed the expression of CD47 to determine whether it affected the oncogenic behavior of colorectal cancer (CRC) and investigated the prognostic value of CD47 expression in patients with CRC. We investigated 468 patients with CRC who underwent curative surgery and examined the expression of CD47 in tumor and lymph node tissues by performing RT-PCR and immunohistochemistry. Apoptosis, proliferation, angiogenesis, and lymphangiogenesis were determined via a TUNEL assay and immunohistochemical staining for Ki-67, CD34, and D2-40. CD47 expression was increased in human CRC tumors and metastatic lymph nodes compared with normal colorectal mucosa and non-metastatic lymph node tissues. CD47 expression was significantly associated with perineural invasion, lymphovascular invasion, cell differentiation, cancer stage, depth of invasion, lymph node metastasis, distant metastasis, and poor survival. The mean apoptotic index and microvessel density value of CD47-positive tumors were significantly higher than those of CD47-negative tumors. However, no significant difference was observed between CD47 expression and Ki-67 labeling index or lymphatic vessel density. These results indicate that CD47 mediated the progression of CRC by inducing tumor cell apoptosis and angiogenesis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Antígeno CD47 Límite: Humans Idioma: En Revista: Pathol Res Pract Año: 2022 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Antígeno CD47 Límite: Humans Idioma: En Revista: Pathol Res Pract Año: 2022 Tipo del documento: Article Pais de publicación: Alemania