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Trait anxiety is related to Nx4's efficacy on stress-induced changes in amygdala-centered resting state functional connectivity: a placebo-controlled cross-over trial in mildly to moderately stressed healthy volunteers.
Nanni-Zepeda, Melanni; Alizadeh, Sarah; Chand, Tara; Kasties, Vanessa; Fan, Yan; van der Meer, Johan; Herrmann, Luisa; Vester, Johannes C; Schulz, Myron; Naschold, Britta; Walter, Martin.
Afiliación
  • Nanni-Zepeda M; Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, 07743, Jena, Germany.
  • Alizadeh S; Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, 07743, Jena, Germany.
  • Chand T; Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, 07743, Jena, Germany.
  • Kasties V; Department of Psychiatry and Psychotherapy, University of Tübingen, Calwerstraße 14, 72076, Tübingen, Germany.
  • Fan Y; Leibniz Research Centre for Working Environment and Human Factors, Ardeystraße 67, 44139, Dortmund, Germany.
  • van der Meer J; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, Netherlands.
  • Herrmann L; Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, 07743, Jena, Germany.
  • Vester JC; idv Data Analysis and Study Planning, Tassilostraße 6, 82131, Gauting, Germany.
  • Schulz M; Biologische Heilmittel Heel GmbH, Dr.-Reckeweg-Str. 2-4, 76532, Baden-Baden, Germany.
  • Naschold B; Biologische Heilmittel Heel GmbH, Dr.-Reckeweg-Str. 2-4, 76532, Baden-Baden, Germany.
  • Walter M; Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, 07743, Jena, Germany. martin.walter@med.uni-jena.de.
BMC Neurosci ; 23(1): 68, 2022 11 24.
Article en En | MEDLINE | ID: mdl-36434512
BACKGROUND: The multicomponent drug Neurexan (Nx4) was shown to reduce the neural stress network activation. We now investigated its effects on stress-induced resting state functional connectivity (RSFC) in dependence of trait anxiety (TA), an acknowledged vulnerability factor for stress-induced psychopathologies. METHODS: Nx4 was tested in a randomized placebo-controlled crossover trial. Resting state fMRI scans were performed before and after a psychosocial stress task and exploratively analyzed for amygdala centered RSFC. Effects of Nx4 on stress-induced RSFC changes were evaluated and correlated to TA levels. A subgroup analysis based on TA scores was performed. RESULTS: Multiple linear regression analysis revealed a significant correlation between TA and Nx4 effect on stress-induced RSFC changes between right amygdala and pregenual anterior cingulate cortex (pgACC) and ventro-medial prefrontal cortex (vmPFC). For participants with above average TA, a significant amelioration of the stress-induced RSFC changes was observed. CONCLUSIONS: The data add evidence to the hypothesis that Nx4's clinical efficacy is based on a dampened activation of the neural stress network, with a greater neural response in subjects with anxious personality traits. Further studies assessing clinically relevant outcome measures in parallel to fMRI are encouraged to evaluate the real-world benefit of Nx4. Trial registration NCT02602275.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ansiedad / Amígdala del Cerebelo Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: BMC Neurosci Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ansiedad / Amígdala del Cerebelo Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: BMC Neurosci Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido