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Hair zinc levels and psychosis risk among adolescents.
Tabata, Koichi; Miyashita, Mitsuhiro; Yamasaki, Syudo; Toriumi, Kazuya; Ando, Shuntaro; Suzuki, Kazuhiro; Endo, Kaori; Morimoto, Yuko; Tomita, Yasufumi; Yamaguchi, Satoshi; Usami, Satoshi; Itokawa, Masanari; Hiraiwa-Hasegawa, Mariko; Takahashi, Hidehiko; Kasai, Kiyoto; Nishida, Atsushi; Arai, Makoto.
Afiliación
  • Tabata K; Schizophrenia Research Project, Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
  • Miyashita M; Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
  • Yamasaki S; Unit for Mental Health Promotion, Research Center for Social Science & Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
  • Toriumi K; Department of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan.
  • Ando S; Unit for Mental Health Promotion, Research Center for Social Science & Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
  • Suzuki K; Schizophrenia Research Project, Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
  • Endo K; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Morimoto Y; Schizophrenia Research Project, Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
  • Tomita Y; Department of Psychiatry, Shinshu University School of Medicine, Matsumoto, Japan.
  • Yamaguchi S; Unit for Mental Health Promotion, Research Center for Social Science & Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
  • Usami S; Department of Psychology, Ube Frontier University, Ube, Japan.
  • Itokawa M; Schizophrenia Research Project, Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
  • Hiraiwa-Hasegawa M; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan.
  • Takahashi H; Unit for Mental Health Promotion, Research Center for Social Science & Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
  • Kasai K; Center for Research and Development on Transition from Secondary to Higher Education, The University of Tokyo, Tokyo, Japan.
  • Nishida A; Schizophrenia Research Project, Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
  • Arai M; Department of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan.
Schizophrenia (Heidelb) ; 8(1): 107, 2022 Nov 25.
Article en En | MEDLINE | ID: mdl-36433958
Recent meta-analyses have shown lower zinc and higher copper levels in the serum of people with schizophrenia than in healthy controls. However, the relationship between trace elements (TEs) and the pathophysiology of psychosis, including schizophrenia, remains unclear due to the antipsychotic effects on mineral levels. In this study, we aimed to determine the relationship between zinc and copper levels in hair and psychosis risk among drug-naïve adolescents. This study was conducted as a part of a population-based biomarker subsample study of the Tokyo Teen Cohort Study, including 252 community-dwelling 14-year-old drug-naïve adolescents. Zinc and copper levels in hair were measured using inductively coupled plasma mass spectrometry. The thought problems (TP) scale from the Child Behavior Checklist was used to evaluate psychosis risk. Regression analysis showed that hair zinc levels were negatively correlated with the TP scale (T-score) (ß = -0.176, P = 0.005). This result remained significant after adjusting for age and sex (ß = -0.175, P = 0.005). In contrast, hair copper levels were not associated with the TP scale (T-score) (ß = 0.026, P = 0.687). These findings suggest that lower zinc levels could be involved in the pathophysiology of psychosis, independent of antipsychotics. Further longitudinal studies are required to investigate whether hair zinc level is a useful new biomarker for assessing psychosis risk.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Idioma: En Revista: Schizophrenia (Heidelb) Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Idioma: En Revista: Schizophrenia (Heidelb) Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Alemania