Your browser doesn't support javascript.
loading
Extensive Collection of Psychotropic Mushrooms with Determination of Their Tryptamine Alkaloids.
Gotvaldová, Klára; Borovicka, Jan; Hájková, Katerina; Cihlárová, Petra; Rockefeller, Alan; Kuchar, Martin.
Afiliación
  • Gotvaldová K; Forensic Laboratory of Biologically Active Substances, Department of Chemistry of Natural Compounds, University of Chemistry and Technology Prague, Technická 5, 166 28 Praha 6-Dejvice, 166 28 Prague, Czech Republic.
  • Borovicka J; Psychedelic Research Centre, National Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech Republic.
  • Hájková K; Nuclear Physics Institute of the Czech Academy of Sciences, Hlavní 130, 250 68 Husinec-Rez, Czech Republic.
  • Cihlárová P; Institute of Geology of the Czech Academy of Sciences, Rozvojová 269, 165 00 Praha 6, 165 00 Prague, Czech Republic.
  • Rockefeller A; Forensic Laboratory of Biologically Active Substances, Department of Chemistry of Natural Compounds, University of Chemistry and Technology Prague, Technická 5, 166 28 Praha 6-Dejvice, 166 28 Prague, Czech Republic.
  • Kuchar M; Psychedelic Research Centre, National Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech Republic.
Int J Mol Sci ; 23(22)2022 Nov 15.
Article en En | MEDLINE | ID: mdl-36430546
Since not only psilocybin (PSB) but also PSB-containing mushrooms are used for psychedelic therapy and microdosing, it is necessary to know their concentration variability in wild-grown mushrooms. This article aimed to determine the PSB, psilocin (PS), baeocystin (BA), norbaeocystin (NB), and aeruginascin (AE) concentrations in a large sample set of mushrooms belonging to genera previously reported to contain psychotropic tryptamines. Ultra-high performance liquid chromatography coupled with tandem mass spectrometry was used to quantify tryptamine alkaloids in the mushroom samples. Most mushroom collections were documented by fungarium specimens and/or ITS rDNA/LSU/EF1-α sequencing. Concentrations of five tryptamine alkaloids were determined in a large sample set of 226 fruiting bodies of 82 individual collections from seven mushroom genera. For many mushroom species, concentrations of BA, NB, and AE are reported for the first time. The highest PSB/PS concentrations were found in Psilocybe species, but no tryptamines were detected in the P. fuscofulva and P. fimetaria collections. The tryptamine concentrations in mushrooms are extremely variable, representing a problem for mushroom consumers due to the apparent risk of overdose. The varied cocktail of tryptamines in wild mushrooms could influence the medicinal effect compared to therapy with chemically pure PSB, posing a serious problem for data interpretation.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Agaricales / Alcaloides Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Agaricales / Alcaloides Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Suiza