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Microbiota Dysbiosis and Gut Barrier Dysfunction Associated with Non-Alcoholic Fatty Liver Disease Are Modulated by a Specific Metabolic Cofactors' Combination.
Quesada-Vázquez, Sergio; Bone, Caitlin; Saha, Shikha; Triguero, Iris; Colom-Pellicer, Marina; Aragonès, Gerard; Hildebrand, Falk; Del Bas, Josep M; Caimari, Antoni; Beraza, Naiara; Escoté, Xavier.
Afiliación
  • Quesada-Vázquez S; Eurecat, Technology Centre of Catalunya, Nutrition and Health Unit, 43204 Reus, Spain.
  • Bone C; Gut Microbes and Health Institute Strategic Programme, Quadram Institute Bioscience, Norwich Research Park, Norwich NR4 7UQ, Norfolk, UK.
  • Saha S; Food Innovation and Health Institute Strategic Programme, Quadram Institute Bioscience, Norwich Research Park, Norwich NR4 7UQ, Norfolk, UK.
  • Triguero I; Eurecat, Technology Centre of Catalunya, Nutrition and Health Unit, 43204 Reus, Spain.
  • Colom-Pellicer M; Nutrigenomics Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43007 Tarragona, Spain.
  • Aragonès G; Nutrigenomics Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43007 Tarragona, Spain.
  • Hildebrand F; Gut Microbes and Health Institute Strategic Programme, Quadram Institute Bioscience, Norwich Research Park, Norwich NR4 7UQ, Norfolk, UK.
  • Del Bas JM; Digital Biology, Earlham Institute, Norwich Research Park, Norwich NR4 7UZ, Norfolk, UK.
  • Caimari A; Eurecat, Centre Tecnològic de Catalunya, Biotechnology Area, 43204 Reus, Spain.
  • Beraza N; Eurecat, Centre Tecnològic de Catalunya, Biotechnology Area, 43204 Reus, Spain.
  • Escoté X; Gut Microbes and Health Institute Strategic Programme, Quadram Institute Bioscience, Norwich Research Park, Norwich NR4 7UQ, Norfolk, UK.
Int J Mol Sci ; 23(22)2022 Nov 08.
Article en En | MEDLINE | ID: mdl-36430154
The gut is a selective barrier that not only allows the translocation of nutrients from food, but also microbe-derived metabolites to the systemic circulation that flows through the liver. Microbiota dysbiosis occurs when energy imbalances appear due to an unhealthy diet and a sedentary lifestyle. Dysbiosis has a critical impact on increasing intestinal permeability and epithelial barrier deterioration, contributing to bacterial and antigen translocation to the liver, triggering non-alcoholic fatty liver disease (NAFLD) progression. In this study, the potential therapeutic/beneficial effects of a combination of metabolic cofactors (a multi-ingredient; MI) (betaine, N-acetylcysteine, L-carnitine, and nicotinamide riboside) against NAFLD were evaluated. In addition, we investigated the effects of this metabolic cofactors' combination as a modulator of other players of the gut-liver axis during the disease, including gut barrier dysfunction and microbiota dysbiosis. Diet-induced NAFLD mice were distributed into two groups, treated with the vehicle (NAFLD group) or with a combination of metabolic cofactors (NAFLD-MI group), and small intestines were harvested from all animals for histological, molecular, and omics analysis. The MI treatment ameliorated gut morphological changes, decreased gut barrier permeability, and reduced gene expression of some proinflammatory cytokines. Moreover, epithelial cell proliferation and the number of goblet cells were increased after MI supplementation. In addition, supplementation with the MI combination promoted changes in the intestinal microbiota composition and diversity, as well as modulating short-chain fatty acids (SCFAs) concentrations in feces. Taken together, this specific combination of metabolic cofactors can reverse gut barrier disruption and microbiota dysbiosis contributing to the amelioration of NAFLD progression by modulating key players of the gut-liver axis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad del Hígado Graso no Alcohólico / Microbioma Gastrointestinal Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad del Hígado Graso no Alcohólico / Microbioma Gastrointestinal Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza