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How We Treat Localized Rectal Cancer-An Institutional Paradigm for Total Neoadjuvant Therapy.
Roeder, Falk; Gerum, Sabine; Hecht, Stefan; Huemer, Florian; Jäger, Tarkan; Kaufmann, Reinhard; Klieser, Eckhard; Koch, Oliver Owen; Neureiter, Daniel; Emmanuel, Klaus; Sedlmayer, Felix; Greil, Richard; Weiss, Lukas.
Afiliación
  • Roeder F; Department of Radiation Oncology, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria.
  • Gerum S; Department of Radiation Oncology, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria.
  • Hecht S; Department of Radiology, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria.
  • Huemer F; Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute-Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR), Center for Clinical Cancer and Immunology Trials (CCCI
  • Jäger T; Department of Visceral and Thoracic Surgery, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria.
  • Kaufmann R; Department of Radiology, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria.
  • Klieser E; Institute of Pathology, Paracelsus Medical University Salzburg, Cancer Cluster Salzburg, 5020 Salzburg, Austria.
  • Koch OO; Department of Visceral and Thoracic Surgery, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria.
  • Neureiter D; Institute of Pathology, Paracelsus Medical University Salzburg, Cancer Cluster Salzburg, 5020 Salzburg, Austria.
  • Emmanuel K; Department of Visceral and Thoracic Surgery, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria.
  • Sedlmayer F; Department of Radiation Oncology, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria.
  • Greil R; Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute-Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR), Center for Clinical Cancer and Immunology Trials (CCCI
  • Weiss L; Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute-Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR), Center for Clinical Cancer and Immunology Trials (CCCI
Cancers (Basel) ; 14(22)2022 Nov 21.
Article en En | MEDLINE | ID: mdl-36428801
Total neoadjuvant therapy (TNT)-the neoadjuvant employment of radiotherapy (RT) or chemoradiation (CRT) as well as chemotherapy (CHT) before surgery-may lead to increased pathological complete response (pCR) rates as well as a reduction in the risk of distant metastases in locally advanced rectal cancer. Furthermore, increased response rates may allow organ-sparing strategies in a growing number of patients with low rectal cancer and upfront immunotherapy has shown very promising early results in patients with microsatellite instability (MSI)-high/mismatch-repair-deficient (dMMR) tumors. Despite the lack of a generally accepted treatment standard, we strongly believe that existing data is sufficient to adopt the concept of TNT and immunotherapy in clinical practice. The treatment algorithm presented in the following is based on our interpretation of the current data and should serve as a practical guide for treating physicians-without any claim to general validity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Suiza