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Adenosine and Adenosine Receptors: Advances in Atrial Fibrillation.
Maille, Baptiste; Lalevée, Nathalie; Marlinge, Marion; Vahdat, Juliette; Mottola, Giovanna; Degioanni, Clara; De Maria, Lucille; Klein, Victor; Thuny, Franck; Franceschi, Frédéric; Deharo, Jean-Claude; Guieu, Régis; Fromonot, Julien.
Afiliación
  • Maille B; Department of Cardiology, Timone University Hospital, 13005 Marseille, France.
  • Lalevée N; Centre for Nutrition and Cardiovascular Disease (C2VN), INSERM, INRAE, Aix Marseille University, 13005 Marseille, France.
  • Marlinge M; Centre for Nutrition and Cardiovascular Disease (C2VN), INSERM, INRAE, Aix Marseille University, 13005 Marseille, France.
  • Vahdat J; Centre for Nutrition and Cardiovascular Disease (C2VN), INSERM, INRAE, Aix Marseille University, 13005 Marseille, France.
  • Mottola G; Laboratory of Biochemistry, Timone University Hospital, AP-HM, 13005 Marseille, France.
  • Degioanni C; Centre for Nutrition and Cardiovascular Disease (C2VN), INSERM, INRAE, Aix Marseille University, 13005 Marseille, France.
  • De Maria L; Centre for Nutrition and Cardiovascular Disease (C2VN), INSERM, INRAE, Aix Marseille University, 13005 Marseille, France.
  • Klein V; Laboratory of Biochemistry, Timone University Hospital, AP-HM, 13005 Marseille, France.
  • Thuny F; Laboratory of Biochemistry, Timone University Hospital, AP-HM, 13005 Marseille, France.
  • Franceschi F; Laboratory of Biochemistry, Timone University Hospital, AP-HM, 13005 Marseille, France.
  • Deharo JC; Department of Cardiology, Timone University Hospital, 13005 Marseille, France.
  • Guieu R; Centre for Nutrition and Cardiovascular Disease (C2VN), INSERM, INRAE, Aix Marseille University, 13005 Marseille, France.
  • Fromonot J; Department of Cardiology, Timone University Hospital, 13005 Marseille, France.
Biomedicines ; 10(11)2022 Nov 17.
Article en En | MEDLINE | ID: mdl-36428533
Atrial fibrillation (AF) is the most common arrhythmia in the world. Because the key to developing innovative therapies that limit the onset and the progression of AF is to fully understand the underlying molecular mechanisms of AF, the aim of the present narrative review is to report the most recent advances in the potential role of the adenosinergic system in the pathophysiology of AF. After a comprehensive approach describing adenosinergic system signaling and the mechanisms of the initiation and maintenance of AF, we address the interactions of the adenosinergic system's signaling with AF. Indeed, adenosine release can activate four G-coupled membrane receptors, named A1, A2A, A2B and A3. Activation of the A2A receptors can promote the occurrence of delayed depolarization, while activation of the A1 receptors can shorten the action potential's duration and induce the resting membrane's potential hyperpolarization, which promote pulmonary vein firing, stabilize the AF rotors and allow for functional reentry. Moreover, the A2B receptors have been associated with atrial fibrosis homeostasis. Finally, the adenosinergic system can modulate the autonomous nervous system and is associated with AF risk factors. A question remains regarding adenosine release and the adenosine receptors' activation and whether this would be a cause or consequence of AF.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Biomedicines Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Biomedicines Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Suiza