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Ackee (Blighia sapida K.D. Koenig) Leaves and Arils Methanolic Extracts Ameliorate CdCl2-Induced Oxidative Stress Biomarkers in Drosophila melanogaster.
Ibraheem, Omodele; Oyewole, Tosin A; Adedara, Adeola; Abolaji, Amos O; Ogundipe, Oluwatobiloba M; Akinyelu, Jude; Eze, Chukwuebuka T; Albogami, Sarah; Alotaibi, Saqer S; Adeyemi, Oluyomi S; Batiha, Gaber El-Saber; Alorabi, Mohammed; De Waard, Michel.
Afiliación
  • Ibraheem O; Plants for Biotechnological Resources Research Group, Department of Biochemistry, Federal University Oye-Ekiti, PMB 373, Oye, Ekiti, Nigeria.
  • Oyewole TA; Plants for Biotechnological Resources Research Group, Department of Biochemistry, Federal University Oye-Ekiti, PMB 373, Oye, Ekiti, Nigeria.
  • Adedara A; Drug Metabolism and Molecular Toxicology Research Laboratories, Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Oyo, Nigeria.
  • Abolaji AO; Drug Metabolism and Molecular Toxicology Research Laboratories, Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Oyo, Nigeria.
  • Ogundipe OM; Plants for Biotechnological Resources Research Group, Department of Biochemistry, Federal University Oye-Ekiti, PMB 373, Oye, Ekiti, Nigeria.
  • Akinyelu J; Nanobiochemistry Research Group, Department of Biochemistry, Federal University Oye-Ekiti, PMB 373, Oye, Ekiti, Nigeria.
  • Eze CT; Environmental Toxicology Research Group, Department of Biochemistry, Federal University Oye-Ekiti, PMB 373, Oye, Ekiti, Nigeria.
  • Albogami S; Department of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
  • Alotaibi SS; Department of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
  • Adeyemi OS; Department of Biochemistry, Medicinal Biochemistry, Nanomedicine & Toxicology Laboratory, Landmark University, PMB, Omu-Aran, 1001, Nigeria.
  • Batiha GE; Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, El Beheira, Egypt.
  • Alorabi M; Department of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
  • De Waard M; Smartox Biotechnology, 6 rue des Platanes, 38120 Saint-Egreve, France.
Oxid Med Cell Longev ; 2022: 3235031, 2022.
Article en En | MEDLINE | ID: mdl-36425055
Different ethnomedical benefits have been documented on different parts of Ackee (Blighia sapida); however, their roles in ameliorating oxidative damages are not well established. CdCl2 inhibitory effects on some oxidative-stress biomarkers and ameliorative potentials of Ackee leaves (AL) and arils (AS) methanolic extracts were studied using Drosophila melanogaster as a model. One to 3-day-old D. melanogaster flies were orally exposed to different concentrations of CdCl2 in their diet for 7 days. The fly's survival profile and negative geotaxis assays were subsequently analysed. Methanolic extracts of AL and AS treatments showed negative geotaxis behaviour, and extracts were able to ameliorate the effect of Cd2+ on catalase and GST activities and increase total thiol and GSH levels, while it reduced the H2O2 generation (p ≤ 0.05) when compared to the control. Furthermore, Cd2+ exhibited noncompetitive and uncompetitive enzyme inhibition on catalase and GST activities, respectively, which may have resulted in the formation of Enzyme-substrate-Cd2+ transition complexes, thus inhibiting the conversion of substrate to product. This study, thus, suggests that the Cd2+ mechanism of toxicity was associated with oxidative damage, as evidenced by the alteration in the oxidative stress-antioxidant imbalance, and that the AL and AS extracts possess essential phytochemicals that could alleviate possibly deleterious oxidative damage effects of environmental pollutants such as CdCl2. Thus, Ackee plant parts possess essential phytonutrients which could serve as valuable resources in heavy metal toxicity management.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Blighia Límite: Animals Idioma: En Revista: Oxid Med Cell Longev Asunto de la revista: METABOLISMO Año: 2022 Tipo del documento: Article País de afiliación: Nigeria Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Blighia Límite: Animals Idioma: En Revista: Oxid Med Cell Longev Asunto de la revista: METABOLISMO Año: 2022 Tipo del documento: Article País de afiliación: Nigeria Pais de publicación: Estados Unidos