Multiple Mutations on &#945;, ß and Î³ Domains of Streptokinase Lead to the Generation of Highly Efficient Cysteine Analogues with Promising Features.

Alinodehi, Narges Norouzzadeh; Behrooz, Hamideh; Sabaei, Milad; Nezamiha, Farahnaz Khoshdel; Mianroodi, Reza Arabi

Multiple Mutations on α, ß and Î³ Domains of Streptokinase Lead to the Generation of Highly Efficient Cysteine Analogues with Promising Features.

Alinodehi, Narges Norouzzadeh; Behrooz, Hamideh; Sabaei, Milad; Nezamiha, Farahnaz Khoshdel; Mianroodi, Reza Arabi.

Afiliación

Alinodehi NN; Department of Genetics and Biotechnology, Faculty of Biological Science, Varamin-Pishva Branch, Islamic Azad, Varamin, Iran.
Behrooz H; Biotechnology Department, Faculty of Pharmaceutical Sciences, Islamic Azad University, Tehran, Iran.
Sabaei M; Antimicrobial Resistance Research Center, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran.
Nezamiha FK; R&D Department, Research and production complex, Pasteur Institute of Iran, Tehran, Iran.
Mianroodi RA; R&D Department, Research and production complex, Pasteur Institute of Iran, Tehran, Iran.

Curr Pharm Biotechnol ; 24(10): 1326-1334, 2023.

Article en En | MEDLINE | ID: mdl-36424778

Asunto(s)

Cisteína; Estreptoquinasa; Estreptoquinasa/genética; Estreptoquinasa/metabolismo; Cisteína/genética; Plasminógeno/química; Plasminógeno/genética; Plasminógeno/metabolismo; Fibrinolíticos; Mutación

Palabras clave

Streptokinase; activity; cysteine; docking; plasminogen; site directed mutagenesis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estreptoquinasa / Cisteína Idioma: En Revista: Curr Pharm Biotechnol Asunto de la revista: BIOTECNOLOGIA / FARMACOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos

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