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Early-Stage Oral Tongue Squamous Cell Carcinoma and a Positive Sentinel Lymph Node Biopsy: Description of a Prognostic Correlation between Pre-Treatment Inflammatory Biomarkers, the Depth of Invasion and the Worst Pattern of Invasion.
Salzano, Giovanni; Togo, Giulia; Maffia, Francesco; Vaira, Luigi Angelo; Maglitto, Fabio; Committeri, Umberto; Fusco, Roberta; Maglione, Maria Grazia; Nocini, Riccardo; De Luca, Pietro; Guida, Agostino; Di Stadio, Arianna; Ferrara, Gerardo; Califano, Luigi; Ionna, Franco.
Afiliación
  • Salzano G; Maxillo-Facial and ENT Surgery Unit, INT-IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.
  • Togo G; Maxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, 80131 Naples, Italy.
  • Maffia F; Maxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, 80131 Naples, Italy.
  • Vaira LA; Maxillofacial Surgery Operative Unit, Department of Medicine, Surgery and Pharmacology, University of Sassari, 07100 Sassari, Italy.
  • Maglitto F; Biomedical Science Department, PhD School of Biomedical Science, University of Sassari, 07100 Sassari, Italy.
  • Committeri U; Maxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, 80131 Naples, Italy.
  • Fusco R; Maxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, 80131 Naples, Italy.
  • Maglione MG; Oncology Medical and Research Development Division, Igea SpA, 80131 Naples, Italy.
  • Nocini R; Maxillo-Facial and ENT Surgery Unit, INT-IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.
  • De Luca P; Unit of Otolaryngology, Head and Neck Department, University of Verona, 37134 Verona, Italy.
  • Guida A; Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.
  • Di Stadio A; U.O.C. Odontostomatologia, AORN A. Cardarelli Hospital, 80131 Naples, Italy.
  • Ferrara G; Otolaryngology Department, University of Catania, 95123 Catania, Italy.
  • Califano L; Department of Pathology, INT-IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.
  • Ionna F; Maxillofacial Surgery Unit, Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, 80131 Naples, Italy.
J Pers Med ; 12(11)2022 Nov 19.
Article en En | MEDLINE | ID: mdl-36422107
The aim of this study was to investigate the correlation between pre-treatment inflammatory biomarkers and the post-operative depth of invasion (DOI) and worst pattern of invasion (WPOI) in early-stage oral tongue squamous cell carcinoma (OTSCC) by means of positive sentinel lymph node biopsy (SLNB). A retrospective analysis of patients affected by cN0 T1-T2 OTSCC who had undergone an SLNB at the National Cancer Institute of Naples was performed. The patients were studied using an evaluation of the pre-treatment neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammatory index (SII), and a histopathological analysis of the DOI and WPOI. The statistical analysis showed that among the prognostic biomarkers, the NLR was a significant predictor of high WPOI values (p = 0.002). The cut-off NLR value was 2.52 with a probability of developing a positive sentinel lymph node biopsy (SLNB) of 30.3%. In contrast, the DOI value was 5.20 with a probability of developing a positive SLNB of 31.82%. Regarding the WPOI, increasing the WPOI class increased the likelihood of a positive SLNB occurrence, and a positive significant correlation was found between the WPOI and SLNB (Csp = 0.342; p < 0.001). Pre-treatment NLR, together with post-surgical DOI and WPOI, can be a reliable predictor of occult neck metastasis in patients affected by early-stage OTSCC with a clinically negative neck. Further prospective studies with a larger series will be needed to confirm the results obtained and to better define the NLR, WPOI and DOI cut-off values in order for elective neck dissection to be recommended in relation to a clinically negative neck.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: J Pers Med Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: J Pers Med Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza