Your browser doesn't support javascript.
loading
Prenatal Antidepressant Exposures and Autism Spectrum Disorder or Traits: A Retrospective, Multi-Cohort Study.
Brennan, Patricia A; Dunlop, Anne L; Croen, Lisa A; Avalos, Lyndsay A; Salisbury, Amy L; Hipwell, Alison E; Nozadi, Sara S; Sathyanarayana, Sheela; Crum, Rosa M; Musci, Rashelle; Li, Mingyi; Li, Xiuhong; Mansolf, Maxwell; O'Connor, Thomas G; Elliott, Amy J; Ghildayal, Nidhi; Lin, Pi-I D; Sprowles, Jenna L N; Stanford, Joseph B; Bendixsen, Casper; Ozonoff, Sally; Lester, Barry M; Shuster, Coral L; Huddleston, Kathi C; Posner, Jonathan; Paneth, Nigel.
Afiliación
  • Brennan PA; Psychology Department, Emory University, 36 Eagle Row, 30322, Atlanta, GA, USA. pbren01@emory.edu.
  • Dunlop AL; Department of Gynecology & Obstetrics, Emory University School of Medicine, Atlanta, GA, USA.
  • Croen LA; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
  • Avalos LA; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
  • Salisbury AL; Virginia Commonwealth University School of Nursing, Richmond, VA, USA.
  • Hipwell AE; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
  • Nozadi SS; Health Sciences Center University of New Mexico, Albuquerque, NM, USA.
  • Sathyanarayana S; Seattle Children's Research Institute, Seattle, WA, USA.
  • Crum RM; University of Washington, Seattle, WA, USA.
  • Musci R; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Li M; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Li X; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Mansolf M; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • O'Connor TG; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Elliott AJ; Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  • Ghildayal N; Departments of Psychiatry, Psychology, Neuroscience, and Obstetrics and Gynecology, University of Rochester, Rochester, NY, USA.
  • Lin PD; Avera Research Institute, Dept of Pediatrics, University of South Dakota School of Medicine, Vermillion, SD, USA.
  • Sprowles JLN; Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
  • Stanford JB; Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
  • Bendixsen C; Beckman Institute for Advanced Science and Technology, University of Illinois Urbana- Champaign, ICF, Urbana, Durham, IL, NC, USA.
  • Ozonoff S; Department of Family and Preventive Medicine, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA.
  • Lester BM; Marshfield Clinic Research Institute, Marshfield Clinic Health System, Marshfield, WI, USA.
  • Shuster CL; Department of Psychiatry and Behavioral Sciences, MIND Institute, University of California Davis, Davis, CA, USA.
  • Huddleston KC; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA.
  • Posner J; Department of Pediatrics, Alpert Medical School of Brown University, Providence, RI, USA.
  • Paneth N; Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence, RI, USA.
Res Child Adolesc Psychopathol ; 51(4): 513-527, 2023 04.
Article en En | MEDLINE | ID: mdl-36417100
Prenatal antidepressant exposure has been associated with increased risk for neurodevelopmental disorders in childhood, including autism spectrum disorder (ASD). The current study utilized multi-cohort data from the Environmental influences on Child Health Outcomes (ECHO) program (N = 3129) to test for this association, and determine whether the association remained after adjusting for maternal prenatal depression and other potential confounders. Antidepressants and a subset of selective serotonin reuptake inhibitors (SSRIs) were examined in relation to binary (e.g., diagnostic) and continuous measures of ASD and ASD related traits (e.g., social difficulties, behavior problems) in children 1.5 to 12 years of age. Child sex was tested as an effect modifier. While prenatal antidepressant exposure was associated with ASD related traits in univariate analyses, these associations were statistically non-significant in models that adjusted for prenatal maternal depression and other maternal and child characteristics. Sex assigned at birth was not an effect modifier for the prenatal antidepressant and child ASD relationship. Overall, we found no association between prenatal antidepressant exposures and ASD diagnoses or traits. Discontinuation of antidepressants in pregnancy does not appear to be warranted on the basis of increased risk for offspring ASD.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Trastorno del Espectro Autista Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Female / Humans / Pregnancy Idioma: En Revista: Res Child Adolesc Psychopathol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Trastorno del Espectro Autista Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Female / Humans / Pregnancy Idioma: En Revista: Res Child Adolesc Psychopathol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos