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Periodontitis is associated with the development of fungal sinusitis: A nationwide 12-year follow-up study.
Kim, Min Gul; Kang, Min Gu; Lee, Min Gyu; Yang, Seong J; Yeom, Sang Woo; Lee, Jong Hwan; Choi, Sang Moon; Yoon, Ji Hyun; Lee, Eun Jung; Noh, Sang Jae; Kim, Min-Su; Kim, Jong Seung.
Afiliación
  • Kim MG; Department of Pharmacology, Jeonbuk National University Medical School, Jeonju, Republic of Korea.
  • Kang MG; Research Institute of Clinical Medicine of Jeonbuk National University - Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Republic of Korea.
  • Lee MG; Department of Medical Informatics, Jeonbuk National University Medical School, Jeonju, Republic of Korea.
  • Yang SJ; Department of Otorhinolaryngology-Head and Neck Surgery, Jeonbuk National University Medical School, Jeonju, Republic of Korea.
  • Yeom SW; Department of Medical Informatics, Jeonbuk National University Medical School, Jeonju, Republic of Korea.
  • Lee JH; Department of Otorhinolaryngology-Head and Neck Surgery, Jeonbuk National University Medical School, Jeonju, Republic of Korea.
  • Choi SM; Department of Statistics (Institute of Applied Statistics), Jeonbuk National University, Jeonju, Republic of Korea.
  • Yoon JH; Department of Medical Informatics, Jeonbuk National University Medical School, Jeonju, Republic of Korea.
  • Lee EJ; Department of Otorhinolaryngology-Head and Neck Surgery, Jeonbuk National University Medical School, Jeonju, Republic of Korea.
  • Noh SJ; Department of Otorhinolaryngology-Head and Neck Surgery, Jeonbuk National University Medical School, Jeonju, Republic of Korea.
  • Kim MS; Doctors Dental Clinic, Gunsan, Republic of Korea.
  • Kim JS; Sae Bom Dental Clinic, Jeonju, Republic of Korea.
J Clin Periodontol ; 50(4): 440-451, 2023 04.
Article en En | MEDLINE | ID: mdl-36415182
AIM: The incidence of fungal sinusitis is increasing; however, its pathophysiology has not been investigated previously. We investigate the effect of periodontitis on the incidence of fungal sinusitis over a 12-year follow-up period using nationwide population-based data. MATERIALS AND METHODS: The periodontitis group was randomly selected from the National Health Insurance Service database. The non-periodontitis group was obtained by propensity score matching considering several variables. The primary end point was the diagnosis of sinonasal fungal balls (SFBs) and invasive fungal sinusitis (IFS). RESULTS: The periodontitis and non-periodontitis groups included 12,442 and 12,442 individuals, respectively. The overall adjusted hazard ratio (aHR) for SFBs in the periodontitis group was 1.46 (p = .002). In subgroup analysis, the aHR for SFBs was 1.59 (p = 0.008) for those with underlying chronic kidney disease (CKD), 1.58 (p = .022) for those with underlying atopic dermatitis, 1.48 (p = .019) for those with chronic obstructive pulmonary disease (COPD), and 1.36 (p = .030) for those with diabetes mellitus (DM), but these values are applicable only when considering the relationship between periodontitis and SFB. The aHR for IFS in the periodontitis group was higher than in the non-periodontitis group (2.80; p = .004). CONCLUSIONS: The risk of SFBs and IFS increased after diagnosis of periodontitis. This trend is often more severe in patients with DM, COPD, or CKD, but this association with underlying diseases is applicable only when considering the association between periodontitis and fungal sinusitis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Periodontitis / Sinusitis / Diabetes Mellitus / Insuficiencia Renal Crónica / Micosis Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Clin Periodontol Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Periodontitis / Sinusitis / Diabetes Mellitus / Insuficiencia Renal Crónica / Micosis Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Clin Periodontol Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos