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Predicting Factors for a Favorable Pathologic Response to Neoadjuvant Therapy in Esophageal Cancer.
Wiesel, Ory; Zlotnik, Oran; Morgenstern, Sarah; Tsur, Maya; Menasherov, Nikolai; Feferman, Yael; Ben-Aharon, Irit; Kashtan, Hanoch.
Afiliación
  • Wiesel O; Department of Surgery.
  • Zlotnik O; Division of Thoracic Surgery, The cardio-Vascular institute, Baruch-Padeh medical center of the North, Poriya, Israel.
  • Morgenstern S; Department of Surgery.
  • Tsur M; Department of Pathology Rabin Medical Center, Petah Tikva, Israel and The Sackler School of Medicine, Tel-Aviv University.
  • Menasherov N; Department of Surgery.
  • Feferman Y; Department of Surgery.
  • Ben-Aharon I; Department of Surgery.
  • Kashtan H; Division of Oncology, Rambam Health Care Campus, Haifa, Israel and The Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
Am J Clin Oncol ; 45(12): 514-518, 2022 12 01.
Article en En | MEDLINE | ID: mdl-36413681
BACKGROUND: Favorable pathologic response(FPR) is a significant predictor for improved survival following Neoadjuvant therapy(NAT) in esophageal and gastroesophageal cancer(GEJ). Preoperative prediction of FPR could modify treatment plans. No reliable method for predicting FPR exists. We sought to identify preoperative predicting factors for FPR. MATERIALS AND METHODS: Retrospective analysis of patients with esophageal and GEJ cancer who underwent esophagectomy following (NAT). Univariate and multivariate analysis was used to identify preoperative predicting factors for FPR. A comparison of Tumor Regression Grade(TRG) was used to assess treatment response on overall survival(OS). RESULTS: Out of 121 patients, 82(67.8%) had neoadjuvant chemoradiation. FPR was observed in 60(49.6%). Female sex, Radiation therapy(RT), squamous cell carcinoma(SCC), lack of signet ring feature, and FDG avidity posttreatment were associated with FPR on univariate analysis. RT and SCC were associated with FPR (OR=3.9 and 4.0, respectively) on multivariate analysis. OS was lower among patients who did not achieve FPR to NAT(P=0.027). CONCLUSIONS: FPR is a predictor of improved OS. SCC and radiation therapy-based protocol were identified as major prediction factors of FPR in patients with esophageal and GEJ cancers.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Esofágicas / Terapia Neoadyuvante Tipo de estudio: Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Am J Clin Oncol Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Esofágicas / Terapia Neoadyuvante Tipo de estudio: Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Am J Clin Oncol Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos