Your browser doesn't support javascript.
loading
Delta oscillation coupled propagating fast ripples precede epileptiform discharges in patients with focal epilepsy.
Weiss, Shennan A; Sheybani, Laurent; Seenarine, Nitish; Fried, Itzhak; Wu, Chengyuan; Sharan, Ashwini; Engel, Jerome; Sperling, Michael R; Nir, Yuval; Staba, Richard J.
Afiliación
  • Weiss SA; Dept. of Neurology, State University of New York Downstate, Brooklyn, New York 11203, USA; Dept. of Physiology and Pharmacology, State University of New York Downstate, Brooklyn, New York 11203, USA; Dept. of Neurology, New York City Health + Hospitals/Kings County, Brooklyn, NY, USA. Electronic add
  • Sheybani L; EEG and Epilepsy Unit / Neurology, Department of Clinical Neuroscience, University Hospitals and Faculty of Medicine of University of Geneva, Geneva, Switzerland; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK.
  • Seenarine N; Dept. of Neurology, State University of New York Downstate, Brooklyn, New York 11203, USA; Dept. of Physiology and Pharmacology, State University of New York Downstate, Brooklyn, New York 11203, USA.
  • Fried I; Dept. of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA.
  • Wu C; Dept. of Neuroradiology, Thomas Jefferson University, Philadelphia, PA, 19107, USA; Dept. of Neurosurgery, Thomas Jefferson University, Philadelphia, PA 19107, USA.
  • Sharan A; Dept. of Neurosurgery, Thomas Jefferson University, Philadelphia, PA 19107, USA.
  • Engel J; Dept. of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA; Dept. of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA; Dept. of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA; Dep
  • Sperling MR; Depts. of Neurology and Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, USA.
  • Nir Y; Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel; The Sieratzki-Sagol Center for Sleep Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Department of Biomedic
  • Staba RJ; Dept. of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA.
Neurobiol Dis ; 175: 105928, 2022 12.
Article en En | MEDLINE | ID: mdl-36403895
Epileptiform spikes are used to localize epileptogenic brain tissue. The mechanisms that spontaneously trigger epileptiform discharges are not yet elucidated. Pathological fast ripple (FR, 200-600 Hz) are biomarkers of epileptogenic brain, and we postulated that FR network interactions are involved in generating epileptiform spikes. Using macroelectrode stereo intracranial EEG (iEEG) recordings from a cohort of 46 patients we found that, in the seizure onset zone (SOZ), propagating FR were more often followed by an epileptiform spike, as compared with non-propagating FR (p < 0.05). Propagating FR had a distinct frequency and larger power (p < 1e-10) and were more strongly phase coupled to the peak of iEEG delta oscillation, which likely correspond with the DOWN states during non-REM sleep (p < 1e-8), than non-propagating FR. While FR propagation was rare, all FR occurred with the highest probability within +/- 400 msec of epileptiform spikes with superimposed high-frequency oscillations (p < 0.05). Thus, a sub-population of epileptiform spikes in the SOZ, are preceded by propagating FR that are coordinated by the DOWN state during non-REM sleep.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Epilepsias Parciales / Ondas Encefálicas Límite: Humans Idioma: En Revista: Neurobiol Dis Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Epilepsias Parciales / Ondas Encefálicas Límite: Humans Idioma: En Revista: Neurobiol Dis Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos