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Chemsex in HIV pre-exposure prophylaxis users: Assessment of mood disorders and addictive behavior.
Peyriere, Hélène; Jacquet, Jean-Marc; Peries, Marianne; Tribout, Vincent; Broche, Béatrice; Mauboussin, Jean-Marc; Makinson, Alain; Perrollaz, Cyril; Ferreyra, Milagros; Rouanet, Isabelle; Montoya-Ferrer, Ana; El-Majjaoui, Said; Corriol-Bonifas, Florence; Fraisse, Thibaut; Grau, Fanny; Laureillard, Didier; Nagot, Nicolas; Reynes, Jacques; Donnadieu-Rigole, Hélène.
Afiliación
  • Peyriere H; INSERM U1175/IRD UMI 233, Montpellier University, Montpellier, France.
  • Jacquet JM; Pathogenesis and Control of Chronic Infections, University of Montpellier, INSERM, EFS, CHU Montpellier, Montpellier, France.
  • Peries M; Department of Addictology, Nimes University Hospital, Nimes, France.
  • Tribout V; Pathogenesis and Control of Chronic Infections, University of Montpellier, INSERM, EFS, CHU Montpellier, Montpellier, France.
  • Broche B; Sexual Transmitted Infections Center, Montpellier University, Montpellier, France.
  • Mauboussin JM; Sexual Transmitted Infections Center, Nimes, France.
  • Makinson A; Infectious Diseases Department, Nimes University Hospital, Nimes, France.
  • Perrollaz C; INSERM U1175/IRD UMI 233, Montpellier University, Montpellier, France.
  • Ferreyra M; Infectious Diseases Department, Montpellier University Hospital, Montpellier, France.
  • Rouanet I; Sexual Transmitted Infections Center, Montpellier University, Montpellier, France.
  • Montoya-Ferrer A; Sexual Transmitted Infections Center, Perpignan, France.
  • El-Majjaoui S; Infectious Diseases Department, Nimes University Hospital, Nimes, France.
  • Corriol-Bonifas F; Infectious Diseases Department, Montpellier University Hospital, Montpellier, France.
  • Fraisse T; Sexual Transmitted Infections Center, Nimes, France.
  • Grau F; Infectious Diseases Department, Alès Hospital, Alès, France.
  • Laureillard D; Infectious Diseases Department, Alès Hospital, Alès, France.
  • Nagot N; Sexual Transmitted Infections Center, Nimes, France.
  • Reynes J; Infectious Diseases Department, Nimes University Hospital, Nimes, France.
  • Donnadieu-Rigole H; Pathogenesis and Control of Chronic Infections, University of Montpellier, INSERM, EFS, CHU Montpellier, Montpellier, France.
Fundam Clin Pharmacol ; 37(3): 639-649, 2023 Jun.
Article en En | MEDLINE | ID: mdl-36403123
The assessment of mood disorders and addiction linked to the practice of chemsex is of interest given the psychoactive substances used. The aim of this study was to assess risky sexual and addictive behavior to chemsex and related anxiety/depression symptoms in individuals receiving HIV pre-exposure prophylaxis (PrEP). In this cross-sectional study, all adults presenting for PrEP renewal at French sexual health centers were enrolled from January 2018 to March 2019. Participants completed a questionnaire on chemsex (i.e., the use of psychoactive substances before/during sex), including adapted Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) to chemsex addiction (questions of ASSIST were modified to focus on chemsex). Anxiety/depression was assessed with the Hospital Anxiety and Depression Scale. In the last 3 months before enrollment, 39.8% (94/236) of participants reported chemsex. The main psychoactive substances consumed during chemsex were cathinones (74.6%), gamma-hydroxybutyrate (66.3%), and other psychostimulants (60%). The median score of the chemsex-focused ASSIST was 8 [IQR25-75 : 3-15]; 72.2% of participants had a score justifying at least a brief intervention (>4). In multivariate analyses, anxiety and cathinones consumption were associated with an ASSIST score >4: OR 13.65 (95% CI 1.68-662.7), P = 0.0062, and OR 8.468 (95% CI 2.066-43.059), P = 0.0014, respectively. The level of addiction to the practice of chemsex can be difficult to estimate for the user, and the ASSIST makes it possible to evaluate this addiction and to direct the subjects toward specialized consultations of addictology, sexual health, or PrEP renewals. The implementation of the modified ASSIST in these consultations can allow early systematic screening and counseling.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Conducta Adictiva / Trastornos Relacionados con Sustancias / Profilaxis Pre-Exposición Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Humans / Male Idioma: En Revista: Fundam Clin Pharmacol Asunto de la revista: FARMACOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Conducta Adictiva / Trastornos Relacionados con Sustancias / Profilaxis Pre-Exposición Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Humans / Male Idioma: En Revista: Fundam Clin Pharmacol Asunto de la revista: FARMACOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido