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Capacity to Consent to Research Among Adolescent-Parent Dyads in Rakai, Uganda.
Kreniske, Philip; Hoffman, Susie; Ddaaki, William; Nakyanjo, Neema; Spindler, Esther; Ssekyewa, Charles; Isabirye, Dauda; Nakubulwa, Rosette; Proscovia, Nabakka; Daniel, Lee; Haba, Nao; Maru, Mahlet; Thompson, Julia; Chen, Ivy S; Nalugoda, Fred; Ssekubugu, Robert; Lutalo, Tom; Ott, Mary A; Santelli, John S.
Afiliación
  • Kreniske P; HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute and Columbia University, New York, NY. Electronic address: pk2361@cumc.columbia.edu.
  • Hoffman S; HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute and Columbia University, New York, NY; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY.
  • Ddaaki W; Rakai Health Sciences Program, Kalisizo, Uganda.
  • Nakyanjo N; Rakai Health Sciences Program, Kalisizo, Uganda.
  • Spindler E; Heilbrunn Department of Population and Family Health, Columbia University Mailman School of Public Health, New York, NY.
  • Ssekyewa C; Rakai Health Sciences Program, Kalisizo, Uganda.
  • Isabirye D; Rakai Health Sciences Program, Kalisizo, Uganda.
  • Nakubulwa R; Rakai Health Sciences Program, Kalisizo, Uganda.
  • Proscovia N; Rakai Health Sciences Program, Kalisizo, Uganda.
  • Daniel L; Department of Sociomedical Sciences, Columbia University Mailman School of Public Health, New York, NY.
  • Haba N; Heilbrunn Department of Population and Family Health, Columbia University Mailman School of Public Health, New York, NY.
  • Maru M; Department of Sociomedical Sciences, Columbia University Mailman School of Public Health, New York, NY.
  • Thompson J; Department of Biostatistics, Columbia University Mailman School of Public Health, New York, NY.
  • Chen IS; Department of Biostatistics, Columbia University Mailman School of Public Health, New York, NY.
  • Nalugoda F; Rakai Health Sciences Program, Kalisizo, Uganda.
  • Ssekubugu R; Rakai Health Sciences Program, Kalisizo, Uganda.
  • Lutalo T; Rakai Health Sciences Program, Kalisizo, Uganda.
  • Ott MA; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN.
  • Santelli JS; Heilbrunn Department of Population and Family Health, Columbia University Mailman School of Public Health, New York, NY.
J Pediatr ; 257: 113271, 2023 06.
Article en En | MEDLINE | ID: mdl-36402433
OBJECTIVES: To assess the cognitive capacity of early, middle, and late adolescents and their parents or guardians to provide informed consent to a population-based cohort study. STUDY DESIGN: Adolescent-parent/guardian dyads including 40 early (n = 80; 10-14 years), 20 middle (15-17 years), and 20 late (18-19 years) adolescents were recruited from the Rakai Community Cohort Study, an open demographic cohort in Uganda. Participants were administered the MacArthur Competence Assessment Tool for Clinical Research, a structured open-ended assessment; interviews were recorded and transcribed. Twenty transcripts were scored independently by two coders; the intraclass correlation coefficient was 0.89. The remaining interviews were scored individually. We compared mean scores for early and middle/late adolescents using a one-sided t test and score differences between parent/guardian and adolescent dyads using two-sided paired t tests. RESULTS: Early adolescents (mean score, 28.8; 95% CI, 27.1-30.5) scored significantly lower (P < .01) than middle/late adolescents (32.4; 31.6-33.1). In paired dyad comparisons, we observed no statistically significant difference in scores between parents/guardians and middle/late adolescents (difference, -0.2; 95% CI, -1.0-0.6). We found a statistically significant difference in scores between parents/guardians and early adolescents (difference, 3.0; 95% CI, 1.2-4.8). CONCLUSIONS: The capacity of adolescents-of different ages and in diverse settings-to comprehend risks, benefits, and other elements of informed consent is a critical but understudied area in research ethics. Our findings support the practice of having middle and late adolescents provide independent informed consent for sexual and reproductive health studies. Early adolescents may benefit from supported decision-making approaches.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Competencia Mental / Consentimiento Informado Tipo de estudio: Observational_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Aspecto: Ethics Límite: Adolescent / Humans País/Región como asunto: Africa Idioma: En Revista: J Pediatr Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Competencia Mental / Consentimiento Informado Tipo de estudio: Observational_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Aspecto: Ethics Límite: Adolescent / Humans País/Región como asunto: Africa Idioma: En Revista: J Pediatr Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos