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Use of antibiotics and risk of type 2 diabetes, overweight and obesity: the Cardiovascular Risk in Young Finns Study and the national FINRISK study.
Nuotio, Joel; Niiranen, Teemu; Laitinen, Tomi T; Miller, Jessica; Sabin, Matthew A; Havulinna, Aki S; Viikari, Jorma S A; Rönnemaa, Tapani; Hutri-Kähönen, Nina; Laitinen, Tomi P; Tossavainen, Päivi; Salomaa, Veikko; Raitakari, Olli T; Burgner, David P; Juonala, Markus.
Afiliación
  • Nuotio J; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, FIN-20520, Turku, Finland. joel.nuotio@utu.fi.
  • Niiranen T; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland. joel.nuotio@utu.fi.
  • Laitinen TT; Heart Center, Turku University Hospital and University of Turku, Turku, Finland. joel.nuotio@utu.fi.
  • Miller J; Murdoch Children's Research Institute, Melbourne, Victoria, Australia. joel.nuotio@utu.fi.
  • Sabin MA; Finnish Institute for Health and Welfare, Helsinki, Finland.
  • Havulinna AS; Department of Internal Medicine, University of Turku, Turku, Finland.
  • Viikari JSA; Division of Medicine, Turku University Hospital, Turku, Finland.
  • Rönnemaa T; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, FIN-20520, Turku, Finland.
  • Hutri-Kähönen N; Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
  • Laitinen TP; Paavo Nurmi Centre, Sports and Exercise Medicine Unit, Department of Physical Activity and Health, University of Turku, Turku, Finland.
  • Tossavainen P; Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
  • Salomaa V; Department of Paediatrics, The University of Melbourne, Melbourne, Victoria, Australia.
  • Raitakari OT; Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
  • Burgner DP; Department of Paediatrics, The University of Melbourne, Melbourne, Victoria, Australia.
  • Juonala M; Department of Endocrinology and Diabetes, The Royal Children's Hospital, Parkville, Victoria, Australia.
BMC Endocr Disord ; 22(1): 284, 2022 Nov 18.
Article en En | MEDLINE | ID: mdl-36401251
PURPOSE: To investigate whether exposure to systemic antibiotics influences the risk of developing type 2 diabetes and overweight/obesity. METHODS: The study sample comprised 2209 (110 with incident diabetes) participants from the population-based Cardiovascular Risk in Young Finns Study (YFS) aged 24-39 years in 2001. The exposure was national linked register data on purchased antibiotic courses between 1993 and 2001. Clinical examinations including BMI were conducted in 2001, 2007 and 2011. Participants with prevalent diabetes in 2001 were excluded. Data on type 2 diabetes was also obtained from two national registers until 2017. Data from four population-based National FINRISK studies were used for replication (N = 24,674, 1866 with incident diabetes). RESULTS: Prior antibiotic exposure (> 5 versus 0-1 antibiotic courses) was associated with subsequent type 2 diabetes in both YFS (OR 2.29; 95%CI 1.33-3.96) and FINRISK (HR 1.73; 95%CI 1.51-1.99). An increased risk for type 2 diabetes was observed in YFS (OR 1.043; 95%CI 1.013-1.074) and FINRISK (HR 1.022; 95%CI 1.016-1.029) per course. Exposure to antibiotics increased the risk of overweight/obesity (BMI > 25 kg/m2) after a 10-year follow-up in YFS (OR 1.043; 95%CI 1.019-1.068) and in FINRISK (OR 1.023; 95%CI 1.018-1.029) at baseline per antibiotic course. Adjustments for confounders from early life in YFS and at baseline in FINRISK, including BMI, socioeconomic status, smoking, insulin, blood pressure, and physical activity, did not appreciably alter the findings. CONCLUSION: Our results show that exposure to antibiotics was associated with increased risk for future type 2 diabetes and overweight/obesity and support judicious antibiotic prescribing.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Diabetes Mellitus Tipo 2 Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: BMC Endocr Disord Año: 2022 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Diabetes Mellitus Tipo 2 Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: BMC Endocr Disord Año: 2022 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Reino Unido