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Polydopamine-coated thalidomide nanocrystals promote DSS-induced murine colitis recovery through Macrophage M2 polarization together with the synergistic anti-inflammatory and anti-angiogenic effects.
Meng, Zhengjie; Fu, Bowen; Yang, Zheng; Xu, Yuhua; Huang, Haixiao; Bai, Yunhao; Fang, Xue; Shen, Shuilin; Yang, Jing; Yong, Jiahui; Tao, Xinyue; Ma, Chenyu; Miao, Wenjun; Ren, Hao; Wang, Yonglu; Xu, Hao; Li, Xueming.
Afiliación
  • Meng Z; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China.
  • Fu B; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China.
  • Yang Z; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China.
  • Xu Y; Jiangsu Health Vocational College, Nanjing 211800, China.
  • Huang H; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China.
  • Bai Y; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China.
  • Fang X; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China.
  • Shen S; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China.
  • Yang J; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China.
  • Yong J; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China.
  • Tao X; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China.
  • Ma C; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China.
  • Miao W; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China.
  • Ren H; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China.
  • Wang Y; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China. Electronic address: yonglu_wang777@163.com.
  • Xu H; Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. Electronic address: mengjames@njtech.edu.cn.
  • Li X; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China. Electronic address: Xuemingli@njtech.edu.cn.
Int J Pharm ; 630: 122376, 2023 Jan 05.
Article en En | MEDLINE | ID: mdl-36400133
High levels of proinflammatory cytokines, macrophage polarization status and immune-mediated angiogenesis play pivotal roles in the pathogenesis of inflammatory bowel disease (IBD). Thalidomide, an anti-inflammatory, immunomodulatory and antiangiogenic agent, is used off-label for treatment of IBD. The therapeutic potential of thalidomide is limited by its poor solubility and side effects associated with its systemic exposure. To address these issues and promote its therapeutic effects on IBD, thalidomide nanocrystals (Thali NCs) were prepared and coated with polydopamine (PDA), a potential macrophage polarization modulator, to form PDA coated Thali NCs (Thali@PDA). Thali@PDA possessed a high drug loading and displayed average particle size of 764.7 ± 50.30 nm. It showed a better anti-colitis effect than bare thalidomide nanocrystals at the same dose of thalidomide. Synergistic effects of polydopamine on anti-inflammatory and anti-angiogenic activities of thalidomide were observed. Furthermore, PDA coating could direct polarization of macrophages towards M2 phenotype, which boosted therapeutic effects of Thali@PDA on IBD. Upon repeated dosing of Thali@PDA for one week, symptoms of IBD in mice were significantly relieved, and histomorphology of the colitis colons were normalized. Key proinflammatory cytokine levels in the inflamed intestines were significantly decreased. Toxicity study also revealed that Thali@PDA is a safe formulation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Colitis / Nanopartículas Límite: Animals Idioma: En Revista: Int J Pharm Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Colitis / Nanopartículas Límite: Animals Idioma: En Revista: Int J Pharm Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos