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Expanding the knowledge around antitubercular 5-(2-aminothiazol-4-yl)isoxazole-3-carboxamides: Hit-to-lead optimization and release of a novel antitubercular chemotype via scaffold derivatization.
Girardini, Miriam; Ferlenghi, Francesca; Annunziato, Giannamaria; Degiacomi, Giulia; Papotti, Bianca; Marchi, Cinzia; Sammartino, José Camilla; Rasheed, Sari S; Contini, Anna; Pasca, Maria Rosalia; Vacondio, Federica; Evans, Joanna C; Dick, Thomas; Müller, Rolf; Costantino, Gabriele; Pieroni, Marco.
Afiliación
  • Girardini M; P4T Group, Italy; Department of Food and Drug, University of Parma, 43124, Parma, Italy.
  • Ferlenghi F; Department of Food and Drug, University of Parma, 43124, Parma, Italy; Centro Interdipartimentale "Biopharmanet-tec", Università degli Studi di Parma, Parma, Italy.
  • Annunziato G; P4T Group, Italy; Department of Food and Drug, University of Parma, 43124, Parma, Italy.
  • Degiacomi G; Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, 27100, Pavia, Italy.
  • Papotti B; Department of Food and Drug, University of Parma, 43124, Parma, Italy.
  • Marchi C; Department of Food and Drug, University of Parma, 43124, Parma, Italy.
  • Sammartino JC; Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, 27100, Pavia, Italy.
  • Rasheed SS; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, Saarland University Campus, 66123, Saarbrücken, Germany; German Centre for Infection Research, partner site Hannover-Braunschweig, Germany.
  • Contini A; P4T Group, Italy; Department of Food and Drug, University of Parma, 43124, Parma, Italy.
  • Pasca MR; Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, 27100, Pavia, Italy.
  • Vacondio F; Department of Food and Drug, University of Parma, 43124, Parma, Italy; Centro Interdipartimentale "Biopharmanet-tec", Università degli Studi di Parma, Parma, Italy.
  • Evans JC; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.
  • Dick T; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA; Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, NJ, USA; Department of Microbiology and Immunology, Georgetown University, Washington DC, USA.
  • Müller R; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research, Saarland University Campus, 66123, Saarbrücken, Germany; German Centre for Infection Research, partner site Hannover-Braunschweig, Germany.
  • Costantino G; P4T Group, Italy; Department of Food and Drug, University of Parma, 43124, Parma, Italy; Centro Interdipartimentale "Biopharmanet-tec", Università degli Studi di Parma, Parma, Italy; Centro Interdipartimentale Misure (CIM) 'G. Casnati', University of Parma, Parma, Italy.
  • Pieroni M; P4T Group, Italy; Department of Food and Drug, University of Parma, 43124, Parma, Italy; Centro Interdipartimentale "Biopharmanet-tec", Università degli Studi di Parma, Parma, Italy. Electronic address: marco.pieroni@unipr.it.
Eur J Med Chem ; 245(Pt 2): 114916, 2023 Jan 05.
Article en En | MEDLINE | ID: mdl-36399878
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Isoxazoles / Mycobacterium tuberculosis Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Francia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Isoxazoles / Mycobacterium tuberculosis Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Francia