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Dually innervated dendritic spines develop in the absence of excitatory activity and resist plasticity through tonic inhibitory crosstalk.
Kleinjan, Mason S; Buchta, William C; Ogelman, Roberto; Hwang, In-Wook; Kuwajima, Masaaki; Hubbard, Dusten D; Kareemo, Dean J; Prikhodko, Olga; Olah, Samantha L; Gomez Wulschner, Luis E; Abraham, Wickliffe C; Franco, Santos J; Harris, Kristen M; Oh, Won Chan; Kennedy, Matthew J.
Afiliación
  • Kleinjan MS; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
  • Buchta WC; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
  • Ogelman R; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
  • Hwang IW; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
  • Kuwajima M; Department of Neuroscience, University of Texas at Austin, Austin, TX 78712, USA.
  • Hubbard DD; Department of Neuroscience, University of Texas at Austin, Austin, TX 78712, USA.
  • Kareemo DJ; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
  • Prikhodko O; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
  • Olah SL; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
  • Gomez Wulschner LE; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
  • Abraham WC; Department of Psychology, Brain Health Research Centre, University of Otago, Dunedin, New Zealand.
  • Franco SJ; Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA.
  • Harris KM; Department of Neuroscience, University of Texas at Austin, Austin, TX 78712, USA.
  • Oh WC; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address: wonchan.oh@cuanschutz.edu.
  • Kennedy MJ; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address: matthew.kennedy@cuanschutz.edu.
Neuron ; 111(3): 362-371.e6, 2023 02 01.
Article en En | MEDLINE | ID: mdl-36395772
Dendritic spines can be directly connected to both inhibitory and excitatory presynaptic terminals, resulting in nanometer-scale proximity of opposing synaptic functions. While dually innervated spines (DiSs) are observed throughout the central nervous system, their developmental timeline and functional properties remain uncharacterized. Here we used a combination of serial section electron microscopy, live imaging, and local synapse activity manipulations to investigate DiS development and function in rodent hippocampus. Dual innervation occurred early in development, even on spines where the excitatory input was locally silenced. Synaptic NMDA receptor currents were selectively reduced at DiSs through tonic GABAB receptor signaling. Accordingly, spine enlargement normally associated with long-term potentiation on singly innervated spines (SiSs) was blocked at DiSs. Silencing somatostatin interneurons or pharmacologically blocking GABABRs restored NMDA receptor function and structural plasticity to levels comparable to neighboring SiSs. Thus, hippocampal DiSs are stable structures where function and plasticity are potently regulated by nanometer-scale GABAergic signaling.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de N-Metil-D-Aspartato / Espinas Dendríticas Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de N-Metil-D-Aspartato / Espinas Dendríticas Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos