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Optical diffraction tomography and image reconstruction to measure host cell alterations caused by divergent Plasmodium species.
Ong, Jessica J Y; Oh, Jeonghun; Yong Ang, Xiang; Naidu, Renugah; Chu, Trang T T; Hyoung Im, Jae; Manzoor, Umar; Kha Nguyen, Tuyet; Na, Seok-Won; Han, Eun-Taek; Davis, Christeen; Sun Park, Won; Chun, Wanjoo; Jun, Hojong; Jin Lee, Se; Na, Sunghun; Chan, Jerry K Y; Park, YongKeun; Russell, Bruce; Chandramohanadas, Rajesh; Han, Jin-Hee.
Afiliación
  • Ong JJY; Department of Microbiology and Immunology, University of Otago, Dunedin 9054, New Zealand.
  • Oh J; Department of Physics, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Institute for Health Science and Technology, KAIST, Daejeon 34141, Republic of Korea.
  • Yong Ang X; Department of Microbiology and Immunology, National University of Singapore, Singapore.
  • Naidu R; Pillar of Engineering Product Development, Singapore University of Technology and Design, Singapore, Singapore.
  • Chu TTT; Pillar of Engineering Product Development, Singapore University of Technology and Design, Singapore, Singapore.
  • Hyoung Im J; Department of Infectious Disease, Inha University School of Medicine, Incheon 22212, Republic of Korea.
  • Manzoor U; Department of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.
  • Kha Nguyen T; Department of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.
  • Na SW; Department of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.
  • Han ET; Department of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.
  • Davis C; DBT Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India; Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
  • Sun Park W; Department of Physiology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.
  • Chun W; Department of Pharmacology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.
  • Jun H; Department of Tropical Medicine, Inha University College of Medicine, Incheon 22212, Republic of Korea.
  • Jin Lee S; Department of Obstetrics and Gynecology, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon 24341, South Korea.
  • Na S; Department of Obstetrics and Gynecology, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon 24341, South Korea.
  • Chan JKY; KK Womens' and Childrens' Hospital, Singapore; Academic Clinical Program in Obstetrics and Gynaecology, Duke-NUS Medical School, 169857, Singapore.
  • Park Y; Department of Physics, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Institute for Health Science and Technology, KAIST, Daejeon 34141, Republic of Korea; Tomocube Inc, Daejeon 34109, Republic of Korea.
  • Russell B; Department of Microbiology and Immunology, University of Otago, Dunedin 9054, New Zealand.
  • Chandramohanadas R; Department of Microbiology and Immunology, National University of Singapore, Singapore; Pillar of Engineering Product Development, Singapore University of Technology and Design, Singapore, Singapore; DBT Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India. Electronic address: ra
  • Han JH; Department of Microbiology and Immunology, University of Otago, Dunedin 9054, New Zealand; Department of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea. Electronic address: han.han@kangwon.ac.kr.
Spectrochim Acta A Mol Biomol Spectrosc ; 286: 122026, 2023 Feb 05.
Article en En | MEDLINE | ID: mdl-36395614
Malaria is a life-threatening infectious disease caused by parasites of the genus Plasmodium. Understanding the biological features of various parasite forms is important for the optical diagnosis and defining pathological states, which are often constrained by the lack of ambient visualization approaches. Here, we employ a label-free tomographic technique to visualize the host red blood cell (RBC) remodeling process and quantify changes in biochemical properties arising from parasitization. Through this, we provide a quantitative body of information pertaining to the influence of host cell environment on growth, survival, and replication of P. falciparum and P. vivax in their respective host cells: mature erythrocytes and young reticulocytes. These exquisite three-dimensional measurements of infected red cells demonstrats the potential of evolving 3D imaging to advance our understanding of Plasmodium biology and host-parasite interactions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasmodium / Malaria Límite: Humans Idioma: En Revista: Spectrochim Acta A Mol Biomol Spectrosc Asunto de la revista: BIOLOGIA MOLECULAR Año: 2023 Tipo del documento: Article País de afiliación: Nueva Zelanda Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasmodium / Malaria Límite: Humans Idioma: En Revista: Spectrochim Acta A Mol Biomol Spectrosc Asunto de la revista: BIOLOGIA MOLECULAR Año: 2023 Tipo del documento: Article País de afiliación: Nueva Zelanda Pais de publicación: Reino Unido