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Histopathologic Evolution of Melanocytes Associated With Rapid Clinical Progression of Melanoma: Clinicopathologic Presentation of Hyperprogressive Disease in a Patient Treated With Immunotherapy.
Almanza, Jocelyn; Dobry, Allison; Ejadi, Samuel; Jakowatz, James; Lee, Bonnie.
Afiliación
  • Almanza J; Department of Dermatology, University of California, Irvine, Irvine, CA.
  • Dobry A; Department of Dermatology, University of California, San Francisco, San Francisco, CA.
  • Ejadi S; Division of Hematology/Oncology, University of California Irvine Medical Center, Orange, CA; and.
  • Jakowatz J; Department of Surgery, University of California, Irvine, Irvine, CA.
  • Lee B; Department of Dermatology, University of California, Irvine, Irvine, CA.
Am J Dermatopathol ; 44(12): 921-924, 2022 Dec 01.
Article en En | MEDLINE | ID: mdl-36395449
ABSTRACT: This report describes the case of a 71-year-old woman with nodular melanoma who experienced rapid clinical deterioration 3 weeks after receiving immunotherapy treatment. Given this presentation, there was high suspicion for tumor hyperprogression, which has been observed as a paradoxical response to the use of immunotherapy in the treatment of melanoma. Histopathologic and genomic changes of primary tumor are documented at several different timepoints relative to immunotherapy treatment that may depict important alterations associated with hyperprogressive disease. To our knowledge, this case is the first to document the evolution of histopathologic features of melanoma associated with hyperprogressive disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Melanoma Tipo de estudio: Risk_factors_studies Límite: Aged / Female / Humans Idioma: En Revista: Am J Dermatopathol Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Melanoma Tipo de estudio: Risk_factors_studies Límite: Aged / Female / Humans Idioma: En Revista: Am J Dermatopathol Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos