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Iodination of PEGylated Polymers Counteracts the Inhibition of Fibrinogen Adsorption by PEG.
Wang, Wenjie; Lindemann, William R; Anderson, Nathaniel A; Kohn, Joachim; Vaknin, David; Murthy, N Sanjeeva.
Afiliación
  • Wang W; Division of Materials Sciences and Engineering, Ames National Laboratory, U.S. DOE, Ames, Iowa50011, United States.
  • Lindemann WR; Division of Materials Sciences and Engineering, Ames National Laboratory, U.S. DOE, Ames, Iowa50011, United States.
  • Anderson NA; Division of Materials Sciences and Engineering, Ames National Laboratory, U.S. DOE, Ames, Iowa50011, United States.
  • Kohn J; Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey08854, United States.
  • Vaknin D; Ames National Laboratory and Department of Physics and Astronomy, Iowa State University, Ames, Iowa50011, United States.
  • Murthy NS; Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey08854, United States.
Langmuir ; 38(48): 14615-14622, 2022 12 06.
Article en En | MEDLINE | ID: mdl-36394992
Poly(ethylene glycol), PEG, known to inhibit protein adsorption, is widely used on the surfaces of biomedical devices when biofilm formation is undesirable. Poly(desaminotyrosyl-tyrosine ethyl ester carbonate), PDTEC, PC for short, has been a promising coating polymer for insertion devices, and it has been anticipated that PEG plays a similar role if it is copolymerized with PC. Earlier studies show that no fibrinogen (Fg) is adsorbed onto PC polymers with PEG beyond the threshold weight percentage. This is attributed to the phase separation of PEG. Further, iodination of the PC units in the PC polymer, (I2PC), has been found to counteract this Fg-repulsive effect by PEG. In this study, we employ surface-sensitive X-ray techniques to demonstrate the surface affinity of Fg toward the air-water interface, particularly in the presence of self-assembled PC-based film, in which its constituent polymer units are assumed to be much more mobile as a free-standing film. Fg is found to form a Gibbs monolayer with its long axis parallel to the aqueous surface, thus maximizing its interactions with hydrophobic interfaces. It influences the amount of insoluble, surface-bound I2PC likely due to the desorption of the formed Fg-I2PC complex and/or the penetration of Fg onto the I2PC film. The results show that the phase behavior at the liquid-polymer interface shall be taken into account for the surface behavior of bulk polymers surrounded by tissue. The ability of PEG units rearranging into a protein-blocking layer, rather than its mere presence in the polymer, is the key to antifouling characteristics desired for polymeric coating on insertion devices.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polímeros / Fibrinógeno Idioma: En Revista: Langmuir Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polímeros / Fibrinógeno Idioma: En Revista: Langmuir Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos