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Engineered nanomaterials trigger abscopal effect in immunotherapy of metastatic cancers.
Xia, Yuanliang; Yang, Ruohan; Zhu, Jianshu; Wang, Hengyi; Li, Yuehong; Fan, Jiawei; Fu, Changfeng.
Afiliación
  • Xia Y; Department of Spine Surgery, The First Hospital of Jilin University, Changchun, China.
  • Yang R; Cancer Center, The First Hospital of Jilin University, Changchun, China.
  • Zhu J; Department of Spine Surgery, The First Hospital of Jilin University, Changchun, China.
  • Wang H; Department of Spine Surgery, The First Hospital of Jilin University, Changchun, China.
  • Li Y; Department of Spine Surgery, The First Hospital of Jilin University, Changchun, China.
  • Fan J; Department of Gastroenterology, The First Hospital of Jilin University, Changchun, China.
  • Fu C; Department of Spine Surgery, The First Hospital of Jilin University, Changchun, China.
Front Bioeng Biotechnol ; 10: 890257, 2022.
Article en En | MEDLINE | ID: mdl-36394039
Despite advances in cancer treatment, metastatic cancer is still the main cause of death in cancer patients. At present, the treatment of metastatic cancer is limited to palliative care. The abscopal effect is a rare phenomenon in which shrinkage of metastatic tumors occurs simultaneously with the shrinkage of a tumor receiving localized treatment, such as local radiotherapy or immunotherapy. Immunotherapy shows promise for cancer treatment, but it also leads to consequences such as low responsiveness and immune-related adverse events. As a promising target-based approach, intravenous or intratumoral injection of nanomaterials provides new opportunities for improving cancer immunotherapy. Chemically modified nanomaterials may be able to trigger the abscopal effect by regulating immune cells. This review discusses the use of nanomaterials in killing metastatic tumor cells through the regulation of immune cells and the prospects of such nanomaterials for clinical use.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Bioeng Biotechnol Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Bioeng Biotechnol Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza